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Identification of novel factors enhancing recombinant protein production in multi-copy Komagataella phaffii based on transcriptomic analysis of overexpression effects

The methylotrophic yeast Komagataella phaffii (Pichia pastoris) has been developed into a highly successful system for heterologous protein expression in both academia and industry. However, overexpression of recombinant protein often leads to severe burden on the physiology of K. phaffii and trigge...

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Detalles Bibliográficos
Autores principales:	Yu, Xiao-Wei, Sun, Wei-Hong, Wang, Ying-Zheng, Xu, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701153/ https://www.ncbi.nlm.nih.gov/pubmed/29176680 http://dx.doi.org/10.1038/s41598-017-16577-x

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