α-Synuclein-Dependent Calcium Entry Underlies Differential Sensitivity of Cultured SN and VTA Dopaminergic Neurons to a Parkinsonian Neurotoxin

Parkinson’s disease (PD) is a debilitating neurodegenerative disease characterized by a loss of dopaminergic neurons in the substantia nigra (SN). Although mitochondrial dysfunction and dysregulated α-synuclein (aSyn) expression are postulated to play a role in PD pathogenesis, it is still debated w...

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Detalles Bibliográficos
Autores principales: Lieberman, Ori J., Choi, Se Joon, Kanter, Ellen, Saverchenko, Anastasia, Frier, Micah D., Fiore, Giulia M., Wu, Min, Kondapalli, Jyothisri, Zampese, Enrico, Surmeier, D. James, Sulzer, David, Mosharov, Eugene V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2017
Materias:
New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701296/
https://www.ncbi.nlm.nih.gov/pubmed/29177188
http://dx.doi.org/10.1523/ENEURO.0167-17.2017

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