P53 at the start of the 21st century: lessons from elephants

Crucial, natural protection against tumour onset in humans is orchestrated by the dynamic protein p53. The best-characterised functions of p53 relate to its cellular stress responses. In this review, we explore emerging insights into p53 activities and their functional consequences. We compare p53 i...

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Detalles Bibliográficos
Autores principales: Haupt, Sue, Haupt, Ygal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701437/
https://www.ncbi.nlm.nih.gov/pubmed/29250320
http://dx.doi.org/10.12688/f1000research.12682.1
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author Haupt, Sue
Haupt, Ygal
author_facet Haupt, Sue
Haupt, Ygal
author_sort Haupt, Sue
collection PubMed
description Crucial, natural protection against tumour onset in humans is orchestrated by the dynamic protein p53. The best-characterised functions of p53 relate to its cellular stress responses. In this review, we explore emerging insights into p53 activities and their functional consequences. We compare p53 in humans and elephants, in search of salient features of cancer protection.
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spelling pubmed-57014372017-12-14 P53 at the start of the 21st century: lessons from elephants Haupt, Sue Haupt, Ygal F1000Res Review Crucial, natural protection against tumour onset in humans is orchestrated by the dynamic protein p53. The best-characterised functions of p53 relate to its cellular stress responses. In this review, we explore emerging insights into p53 activities and their functional consequences. We compare p53 in humans and elephants, in search of salient features of cancer protection. F1000 Research Limited 2017-11-22 /pmc/articles/PMC5701437/ /pubmed/29250320 http://dx.doi.org/10.12688/f1000research.12682.1 Text en Copyright: © 2017 Haupt S and Haupt Y http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Haupt, Sue
Haupt, Ygal
P53 at the start of the 21st century: lessons from elephants
title P53 at the start of the 21st century: lessons from elephants
title_full P53 at the start of the 21st century: lessons from elephants
title_fullStr P53 at the start of the 21st century: lessons from elephants
title_full_unstemmed P53 at the start of the 21st century: lessons from elephants
title_short P53 at the start of the 21st century: lessons from elephants
title_sort p53 at the start of the 21st century: lessons from elephants
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701437/
https://www.ncbi.nlm.nih.gov/pubmed/29250320
http://dx.doi.org/10.12688/f1000research.12682.1
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