Cargando…

Patient- and treatment-related risk factors associated with neck muscle spasm in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy

BACKGROUND: To evaluate the incidence of neck muscle spasm in nasopharyngeal carcinoma (NPC) patients that received intensity-modulated radiotherapy (IMRT), and to analyse the patient- and treatment-related risk factors associated with neck muscle spasm. METHODS: A sample of 152 IMRT-treated, biopsy...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Lu-Lu, Zhou, Guan-Qun, Qi, Zhen-Yu, He, Xiao-Jun, Li, Jia-Xiang, Tang, Ling-Long, Mao, Yan-Ping, Lin, Ai-Hua, Ma, Jun, Sun, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701496/
https://www.ncbi.nlm.nih.gov/pubmed/29169335
http://dx.doi.org/10.1186/s12885-017-3780-9
_version_ 1783281354788569088
author Zhang, Lu-Lu
Zhou, Guan-Qun
Qi, Zhen-Yu
He, Xiao-Jun
Li, Jia-Xiang
Tang, Ling-Long
Mao, Yan-Ping
Lin, Ai-Hua
Ma, Jun
Sun, Ying
author_facet Zhang, Lu-Lu
Zhou, Guan-Qun
Qi, Zhen-Yu
He, Xiao-Jun
Li, Jia-Xiang
Tang, Ling-Long
Mao, Yan-Ping
Lin, Ai-Hua
Ma, Jun
Sun, Ying
author_sort Zhang, Lu-Lu
collection PubMed
description BACKGROUND: To evaluate the incidence of neck muscle spasm in nasopharyngeal carcinoma (NPC) patients that received intensity-modulated radiotherapy (IMRT), and to analyse the patient- and treatment-related risk factors associated with neck muscle spasm. METHODS: A sample of 152 IMRT-treated, biopsy-proven, nondisseminated NPC patients were retrospectively analysed. All had documented IMRT treatment plans and had returned for follow-up review at 4 years post-radiotherapy. Spasm of the sternocleidomastoid (SCM) muscle was graded from 0 to 3 (absent to severe) and this grade served as the clinical endpoint. Risk factors were identified using logistic regression analysis. RESULTS: Within 4 years of radiotherapy, neck muscle spasm developed in 23.68% of the patients; Grades 0, 1, 2 and 3 were respectively assigned to 83.55, 7.57, 6.58 and 2.30% of assessed SCMs. Multivariate analysis indicated that gender, N stage, V60 (percentage of SCM volume that received >60 Gy) were independent prognostic variables, and that the optimal threshold for using V60 to predict neck muscle spasm was 61.92% (sensitivity = 0.900, specificity = 0.953). CONCLUSIONS: Gender, N stage and V60 were independent predictive factors for post-radiotherapy neck muscle spasm, and a V60 of ≤61.92% in the SCM was relatively safe.
format Online
Article
Text
id pubmed-5701496
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-57014962017-12-04 Patient- and treatment-related risk factors associated with neck muscle spasm in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy Zhang, Lu-Lu Zhou, Guan-Qun Qi, Zhen-Yu He, Xiao-Jun Li, Jia-Xiang Tang, Ling-Long Mao, Yan-Ping Lin, Ai-Hua Ma, Jun Sun, Ying BMC Cancer Research Article BACKGROUND: To evaluate the incidence of neck muscle spasm in nasopharyngeal carcinoma (NPC) patients that received intensity-modulated radiotherapy (IMRT), and to analyse the patient- and treatment-related risk factors associated with neck muscle spasm. METHODS: A sample of 152 IMRT-treated, biopsy-proven, nondisseminated NPC patients were retrospectively analysed. All had documented IMRT treatment plans and had returned for follow-up review at 4 years post-radiotherapy. Spasm of the sternocleidomastoid (SCM) muscle was graded from 0 to 3 (absent to severe) and this grade served as the clinical endpoint. Risk factors were identified using logistic regression analysis. RESULTS: Within 4 years of radiotherapy, neck muscle spasm developed in 23.68% of the patients; Grades 0, 1, 2 and 3 were respectively assigned to 83.55, 7.57, 6.58 and 2.30% of assessed SCMs. Multivariate analysis indicated that gender, N stage, V60 (percentage of SCM volume that received >60 Gy) were independent prognostic variables, and that the optimal threshold for using V60 to predict neck muscle spasm was 61.92% (sensitivity = 0.900, specificity = 0.953). CONCLUSIONS: Gender, N stage and V60 were independent predictive factors for post-radiotherapy neck muscle spasm, and a V60 of ≤61.92% in the SCM was relatively safe. BioMed Central 2017-11-23 /pmc/articles/PMC5701496/ /pubmed/29169335 http://dx.doi.org/10.1186/s12885-017-3780-9 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Zhang, Lu-Lu
Zhou, Guan-Qun
Qi, Zhen-Yu
He, Xiao-Jun
Li, Jia-Xiang
Tang, Ling-Long
Mao, Yan-Ping
Lin, Ai-Hua
Ma, Jun
Sun, Ying
Patient- and treatment-related risk factors associated with neck muscle spasm in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy
title Patient- and treatment-related risk factors associated with neck muscle spasm in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy
title_full Patient- and treatment-related risk factors associated with neck muscle spasm in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy
title_fullStr Patient- and treatment-related risk factors associated with neck muscle spasm in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy
title_full_unstemmed Patient- and treatment-related risk factors associated with neck muscle spasm in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy
title_short Patient- and treatment-related risk factors associated with neck muscle spasm in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy
title_sort patient- and treatment-related risk factors associated with neck muscle spasm in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701496/
https://www.ncbi.nlm.nih.gov/pubmed/29169335
http://dx.doi.org/10.1186/s12885-017-3780-9
work_keys_str_mv AT zhanglulu patientandtreatmentrelatedriskfactorsassociatedwithneckmusclespasminnasopharyngealcarcinomapatientsafterintensitymodulatedradiotherapy
AT zhouguanqun patientandtreatmentrelatedriskfactorsassociatedwithneckmusclespasminnasopharyngealcarcinomapatientsafterintensitymodulatedradiotherapy
AT qizhenyu patientandtreatmentrelatedriskfactorsassociatedwithneckmusclespasminnasopharyngealcarcinomapatientsafterintensitymodulatedradiotherapy
AT hexiaojun patientandtreatmentrelatedriskfactorsassociatedwithneckmusclespasminnasopharyngealcarcinomapatientsafterintensitymodulatedradiotherapy
AT lijiaxiang patientandtreatmentrelatedriskfactorsassociatedwithneckmusclespasminnasopharyngealcarcinomapatientsafterintensitymodulatedradiotherapy
AT tanglinglong patientandtreatmentrelatedriskfactorsassociatedwithneckmusclespasminnasopharyngealcarcinomapatientsafterintensitymodulatedradiotherapy
AT maoyanping patientandtreatmentrelatedriskfactorsassociatedwithneckmusclespasminnasopharyngealcarcinomapatientsafterintensitymodulatedradiotherapy
AT linaihua patientandtreatmentrelatedriskfactorsassociatedwithneckmusclespasminnasopharyngealcarcinomapatientsafterintensitymodulatedradiotherapy
AT majun patientandtreatmentrelatedriskfactorsassociatedwithneckmusclespasminnasopharyngealcarcinomapatientsafterintensitymodulatedradiotherapy
AT sunying patientandtreatmentrelatedriskfactorsassociatedwithneckmusclespasminnasopharyngealcarcinomapatientsafterintensitymodulatedradiotherapy