The Cks1/Cks2 axis fine-tunes Mll1 expression and is crucial for MLL-rearranged leukaemia cell viability

The Cdc28 protein kinase subunits, Cks1 and Cks2, play dual roles in Cdk-substrate specificity and Cdk-independent protein degradation, in concert with the E3 ubiquitin ligase complexes SCF(Skp2) and APC(Cdc20). Notable targets controlled by Cks include p27 and Cyclin A. Here, we demonstrate that Ck...

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Detalles Bibliográficos
Autores principales: Grey, William, Ivey, Adam, Milne, Thomas A., Haferlach, Torsten, Grimwade, David, Uhlmann, Frank, Voisset, Edwige, Yu, Veronica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Pub. Co 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701546/
https://www.ncbi.nlm.nih.gov/pubmed/28939057
http://dx.doi.org/10.1016/j.bbamcr.2017.09.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701546/
https://www.ncbi.nlm.nih.gov/pubmed/28939057
http://dx.doi.org/10.1016/j.bbamcr.2017.09.009

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