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The Cks1/Cks2 axis fine-tunes Mll1 expression and is crucial for MLL-rearranged leukaemia cell viability
The Cdc28 protein kinase subunits, Cks1 and Cks2, play dual roles in Cdk-substrate specificity and Cdk-independent protein degradation, in concert with the E3 ubiquitin ligase complexes SCF(Skp2) and APC(Cdc20). Notable targets controlled by Cks include p27 and Cyclin A. Here, we demonstrate that Ck...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Pub. Co
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701546/ https://www.ncbi.nlm.nih.gov/pubmed/28939057 http://dx.doi.org/10.1016/j.bbamcr.2017.09.009 |