Cargando…
Malignant acanthosis nigricans: an early diagnostic clue for gastric adenocarcinoma
BACKGROUND: Malignant acanthosis nigricans (MAN), characterized by the presence of a hyperpigmented, velvety cutaneous thickening, is recognized as a cutaneous sign of internal malignancy. Few MAN has been reported in the Asian race ever before. CASE PRESENTATION: Here, we report a rare case of MAN...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702104/ https://www.ncbi.nlm.nih.gov/pubmed/29178944 http://dx.doi.org/10.1186/s12957-017-1274-5 |
_version_ | 1783281455604957184 |
---|---|
author | Yu, Qian Li, Xiu-Li Ji, Guo Wang, Yao Gong, Yu Xu, Hui Shi, Yu-Ling |
author_facet | Yu, Qian Li, Xiu-Li Ji, Guo Wang, Yao Gong, Yu Xu, Hui Shi, Yu-Ling |
author_sort | Yu, Qian |
collection | PubMed |
description | BACKGROUND: Malignant acanthosis nigricans (MAN), characterized by the presence of a hyperpigmented, velvety cutaneous thickening, is recognized as a cutaneous sign of internal malignancy. Few MAN has been reported in the Asian race ever before. CASE PRESENTATION: Here, we report a rare case of MAN with severe mucosa and soles and extraordinary facial involvement in the Asian race. A 74-year-old man presented with hyperkeratotic eruption for 7 months. Physical examination revealed hyperkeratotic plaques on the face, dorsal skin of fingers and heels, and papillomatosis of buccal mucosa. Biopsy findings from skin lesion revealed hyperkeratosis, papillomatosis, and hyperpigmentation of the basal layer. The endoscopic ultrasound with biopsy of the gastric tissue revealed gastric cardia tubular adenocarcinoma. The patient was diagnosed with MAN associated with gastric adenocarcinoma, immediately following tumor resection and lymphadenectomy. A slight improvement was seen in the skin condition but died of cancer cachexia 3 months later. CONCLUSIONS: We report our typical patient to highlight the importance of MAN, which was an early clue to the discovery of gastric adenocarcinoma. |
format | Online Article Text |
id | pubmed-5702104 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-57021042017-12-04 Malignant acanthosis nigricans: an early diagnostic clue for gastric adenocarcinoma Yu, Qian Li, Xiu-Li Ji, Guo Wang, Yao Gong, Yu Xu, Hui Shi, Yu-Ling World J Surg Oncol Case Report BACKGROUND: Malignant acanthosis nigricans (MAN), characterized by the presence of a hyperpigmented, velvety cutaneous thickening, is recognized as a cutaneous sign of internal malignancy. Few MAN has been reported in the Asian race ever before. CASE PRESENTATION: Here, we report a rare case of MAN with severe mucosa and soles and extraordinary facial involvement in the Asian race. A 74-year-old man presented with hyperkeratotic eruption for 7 months. Physical examination revealed hyperkeratotic plaques on the face, dorsal skin of fingers and heels, and papillomatosis of buccal mucosa. Biopsy findings from skin lesion revealed hyperkeratosis, papillomatosis, and hyperpigmentation of the basal layer. The endoscopic ultrasound with biopsy of the gastric tissue revealed gastric cardia tubular adenocarcinoma. The patient was diagnosed with MAN associated with gastric adenocarcinoma, immediately following tumor resection and lymphadenectomy. A slight improvement was seen in the skin condition but died of cancer cachexia 3 months later. CONCLUSIONS: We report our typical patient to highlight the importance of MAN, which was an early clue to the discovery of gastric adenocarcinoma. BioMed Central 2017-11-25 /pmc/articles/PMC5702104/ /pubmed/29178944 http://dx.doi.org/10.1186/s12957-017-1274-5 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Yu, Qian Li, Xiu-Li Ji, Guo Wang, Yao Gong, Yu Xu, Hui Shi, Yu-Ling Malignant acanthosis nigricans: an early diagnostic clue for gastric adenocarcinoma |
title | Malignant acanthosis nigricans: an early diagnostic clue for gastric adenocarcinoma |
title_full | Malignant acanthosis nigricans: an early diagnostic clue for gastric adenocarcinoma |
title_fullStr | Malignant acanthosis nigricans: an early diagnostic clue for gastric adenocarcinoma |
title_full_unstemmed | Malignant acanthosis nigricans: an early diagnostic clue for gastric adenocarcinoma |
title_short | Malignant acanthosis nigricans: an early diagnostic clue for gastric adenocarcinoma |
title_sort | malignant acanthosis nigricans: an early diagnostic clue for gastric adenocarcinoma |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702104/ https://www.ncbi.nlm.nih.gov/pubmed/29178944 http://dx.doi.org/10.1186/s12957-017-1274-5 |
work_keys_str_mv | AT yuqian malignantacanthosisnigricansanearlydiagnosticclueforgastricadenocarcinoma AT lixiuli malignantacanthosisnigricansanearlydiagnosticclueforgastricadenocarcinoma AT jiguo malignantacanthosisnigricansanearlydiagnosticclueforgastricadenocarcinoma AT wangyao malignantacanthosisnigricansanearlydiagnosticclueforgastricadenocarcinoma AT gongyu malignantacanthosisnigricansanearlydiagnosticclueforgastricadenocarcinoma AT xuhui malignantacanthosisnigricansanearlydiagnosticclueforgastricadenocarcinoma AT shiyuling malignantacanthosisnigricansanearlydiagnosticclueforgastricadenocarcinoma |