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Nutritional supplements and herbal medicines for women with polycystic ovary syndrome; a systematic review and meta-analysis
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common, reproductive endocrinopathy associated with serious short and long term health risks. Many women with PCOS use ingestible complementary medicines. This systematic review examined the effect on menstrual regulation and adverse effects from ran...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702141/ https://www.ncbi.nlm.nih.gov/pubmed/29178904 http://dx.doi.org/10.1186/s12906-017-2011-x |
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author | Arentz, Susan Smith, Caroline A. Abbott, Jason Bensoussan, Alan |
author_facet | Arentz, Susan Smith, Caroline A. Abbott, Jason Bensoussan, Alan |
author_sort | Arentz, Susan |
collection | PubMed |
description | BACKGROUND: Polycystic ovary syndrome (PCOS) is a common, reproductive endocrinopathy associated with serious short and long term health risks. Many women with PCOS use ingestible complementary medicines. This systematic review examined the effect on menstrual regulation and adverse effects from randomised controlled trials. METHODS: Randomised controlled trials (RCTs) that compared herbal or nutritional supplements to placebo or active controls in women with PCOS were eligible for inclusion. Electronic databases were searched to July 2017. Study selection and assessment of quality were conducted independently by two review authors. RESULTS: Twenty four studies (1406 women) investigating seven nutritional supplements and four herbal medicines were included. No one study was assessed as having a low risk of bias. Four trials reported on the primary endpoint menstrual regulation. There was no evidence on improved menstrual regularity for calcium plus vitamin D compared to Metformin (RR: 0.66, 95% CI 0.35 to 1.23, p = 0.19), reduced amenorrhoea for Camellia sinensis compared to placebo (RR: 0.17, 95% CI 0.02 to 1.72, p = 0.13) and no difference in the number of menses per month for Cinnamomum sp. against placebo (MD 0.05, 95% CI -0.36 to 1.36, p = 0.26). Adverse effects were investigated in seven studies (164 women). Mild adverse effects were found for Cinnamomum sp. compared to placebo (17 women, RR: 0.36, 95% CI 0.03 to 0.70, p = 0.03). No difference was found for adverse effects between inositol, B complex vitamins, vitamin D, chromium and placebo. Improved reproduction, metabolic hormones and hyperandrogenism was found for inositol and improved cholesterol for omega three fish oils. CONCLUSION: There is no high quality evidence to support the effectiveness of nutritional supplements and herbal medicine for women with PCOS and evidence of safety is lacking. High quality trials of nutritional supplements and herbal medicines examining menstrual regulation and adverse effects in women with PCOS are needed. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12906-017-2011-x) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5702141 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-57021412017-12-04 Nutritional supplements and herbal medicines for women with polycystic ovary syndrome; a systematic review and meta-analysis Arentz, Susan Smith, Caroline A. Abbott, Jason Bensoussan, Alan BMC Complement Altern Med Research Article BACKGROUND: Polycystic ovary syndrome (PCOS) is a common, reproductive endocrinopathy associated with serious short and long term health risks. Many women with PCOS use ingestible complementary medicines. This systematic review examined the effect on menstrual regulation and adverse effects from randomised controlled trials. METHODS: Randomised controlled trials (RCTs) that compared herbal or nutritional supplements to placebo or active controls in women with PCOS were eligible for inclusion. Electronic databases were searched to July 2017. Study selection and assessment of quality were conducted independently by two review authors. RESULTS: Twenty four studies (1406 women) investigating seven nutritional supplements and four herbal medicines were included. No one study was assessed as having a low risk of bias. Four trials reported on the primary endpoint menstrual regulation. There was no evidence on improved menstrual regularity for calcium plus vitamin D compared to Metformin (RR: 0.66, 95% CI 0.35 to 1.23, p = 0.19), reduced amenorrhoea for Camellia sinensis compared to placebo (RR: 0.17, 95% CI 0.02 to 1.72, p = 0.13) and no difference in the number of menses per month for Cinnamomum sp. against placebo (MD 0.05, 95% CI -0.36 to 1.36, p = 0.26). Adverse effects were investigated in seven studies (164 women). Mild adverse effects were found for Cinnamomum sp. compared to placebo (17 women, RR: 0.36, 95% CI 0.03 to 0.70, p = 0.03). No difference was found for adverse effects between inositol, B complex vitamins, vitamin D, chromium and placebo. Improved reproduction, metabolic hormones and hyperandrogenism was found for inositol and improved cholesterol for omega three fish oils. CONCLUSION: There is no high quality evidence to support the effectiveness of nutritional supplements and herbal medicine for women with PCOS and evidence of safety is lacking. High quality trials of nutritional supplements and herbal medicines examining menstrual regulation and adverse effects in women with PCOS are needed. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12906-017-2011-x) contains supplementary material, which is available to authorized users. BioMed Central 2017-11-25 /pmc/articles/PMC5702141/ /pubmed/29178904 http://dx.doi.org/10.1186/s12906-017-2011-x Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Arentz, Susan Smith, Caroline A. Abbott, Jason Bensoussan, Alan Nutritional supplements and herbal medicines for women with polycystic ovary syndrome; a systematic review and meta-analysis |
title | Nutritional supplements and herbal medicines for women with polycystic ovary syndrome; a systematic review and meta-analysis |
title_full | Nutritional supplements and herbal medicines for women with polycystic ovary syndrome; a systematic review and meta-analysis |
title_fullStr | Nutritional supplements and herbal medicines for women with polycystic ovary syndrome; a systematic review and meta-analysis |
title_full_unstemmed | Nutritional supplements and herbal medicines for women with polycystic ovary syndrome; a systematic review and meta-analysis |
title_short | Nutritional supplements and herbal medicines for women with polycystic ovary syndrome; a systematic review and meta-analysis |
title_sort | nutritional supplements and herbal medicines for women with polycystic ovary syndrome; a systematic review and meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702141/ https://www.ncbi.nlm.nih.gov/pubmed/29178904 http://dx.doi.org/10.1186/s12906-017-2011-x |
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