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Blocking ATP-sensitive potassium channel alleviates morphine tolerance by inhibiting HSP70-TLR4-NLRP3-mediated neuroinflammation

BACKGROUND: Long-term use of morphine induces analgesic tolerance, which limits its clinical efficacy. Evidence indicated morphine-evoked neuroinflammation mediated by toll-like receptor 4 (TLR4) - NOD-like receptor protein 3 (NLRP3) inflammasome was important for morphine tolerance. In our study, w...

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Detalles Bibliográficos
Autores principales:	Qu, Jie, Tao, Xue-You, Teng, Peng, Zhang, Yan, Guo, Ci-Liang, Hu, Liang, Qian, Yan-Ning, Jiang, Chun-Yi, Liu, Wen-Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702153/ https://www.ncbi.nlm.nih.gov/pubmed/29178967 http://dx.doi.org/10.1186/s12974-017-0997-0

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