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Severe hypertriglyceridemia and colchicine intoxication following suicide attempt

Colchicine overdose is uncommon but potentially life threatening. Due to its serious adverse systemic effects, overdose must be recognized and treated. We report a case of an 18-year-old female who ingested 18 mg (~0.4 mg/kg) of colchicine in a suicide attempt. The patient’s clinical manifestations...

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Autores principales: Lev, Shaul, Snyder, David, Azran, Carmil, Zolotarsky, Victor, Dahan, Arik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702170/
https://www.ncbi.nlm.nih.gov/pubmed/29200827
http://dx.doi.org/10.2147/DDDT.S140574
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author Lev, Shaul
Snyder, David
Azran, Carmil
Zolotarsky, Victor
Dahan, Arik
author_facet Lev, Shaul
Snyder, David
Azran, Carmil
Zolotarsky, Victor
Dahan, Arik
author_sort Lev, Shaul
collection PubMed
description Colchicine overdose is uncommon but potentially life threatening. Due to its serious adverse systemic effects, overdose must be recognized and treated. We report a case of an 18-year-old female who ingested 18 mg (~0.4 mg/kg) of colchicine in a suicide attempt. The patient’s clinical manifestations included abdominal cramps, vomiting, pancytopenia, hypocholesterolemia, and rhabdomyolysis. Two unique manifestations of toxicity in this patient were profound and persistent, severe hypertriglyceridemia and electrolyte imbalance, mainly hypophosphatemia, with no other evident cause except the colchicine intoxication. Following intensive supportive treatment, including ventilator support, N-acetylcysteine, granulocyte colony stimulating factor, electrolyte repletion, and zinc supplementation, the patient made a complete recovery. Colchicine intoxication is a severe, life-threatening situation that should be followed closely in intensive care units. Severe changes in body functions can rapidly develop, as previously described in the literature. To our knowledge, this extremely elevated triglyceride level has never been reported without the administration of propofol, and requires further evaluation.
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spelling pubmed-57021702017-11-30 Severe hypertriglyceridemia and colchicine intoxication following suicide attempt Lev, Shaul Snyder, David Azran, Carmil Zolotarsky, Victor Dahan, Arik Drug Des Devel Ther Case Report Colchicine overdose is uncommon but potentially life threatening. Due to its serious adverse systemic effects, overdose must be recognized and treated. We report a case of an 18-year-old female who ingested 18 mg (~0.4 mg/kg) of colchicine in a suicide attempt. The patient’s clinical manifestations included abdominal cramps, vomiting, pancytopenia, hypocholesterolemia, and rhabdomyolysis. Two unique manifestations of toxicity in this patient were profound and persistent, severe hypertriglyceridemia and electrolyte imbalance, mainly hypophosphatemia, with no other evident cause except the colchicine intoxication. Following intensive supportive treatment, including ventilator support, N-acetylcysteine, granulocyte colony stimulating factor, electrolyte repletion, and zinc supplementation, the patient made a complete recovery. Colchicine intoxication is a severe, life-threatening situation that should be followed closely in intensive care units. Severe changes in body functions can rapidly develop, as previously described in the literature. To our knowledge, this extremely elevated triglyceride level has never been reported without the administration of propofol, and requires further evaluation. Dove Medical Press 2017-11-22 /pmc/articles/PMC5702170/ /pubmed/29200827 http://dx.doi.org/10.2147/DDDT.S140574 Text en © 2017 Lev et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Case Report
Lev, Shaul
Snyder, David
Azran, Carmil
Zolotarsky, Victor
Dahan, Arik
Severe hypertriglyceridemia and colchicine intoxication following suicide attempt
title Severe hypertriglyceridemia and colchicine intoxication following suicide attempt
title_full Severe hypertriglyceridemia and colchicine intoxication following suicide attempt
title_fullStr Severe hypertriglyceridemia and colchicine intoxication following suicide attempt
title_full_unstemmed Severe hypertriglyceridemia and colchicine intoxication following suicide attempt
title_short Severe hypertriglyceridemia and colchicine intoxication following suicide attempt
title_sort severe hypertriglyceridemia and colchicine intoxication following suicide attempt
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702170/
https://www.ncbi.nlm.nih.gov/pubmed/29200827
http://dx.doi.org/10.2147/DDDT.S140574
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