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Severe hypertriglyceridemia and colchicine intoxication following suicide attempt
Colchicine overdose is uncommon but potentially life threatening. Due to its serious adverse systemic effects, overdose must be recognized and treated. We report a case of an 18-year-old female who ingested 18 mg (~0.4 mg/kg) of colchicine in a suicide attempt. The patient’s clinical manifestations...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702170/ https://www.ncbi.nlm.nih.gov/pubmed/29200827 http://dx.doi.org/10.2147/DDDT.S140574 |
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author | Lev, Shaul Snyder, David Azran, Carmil Zolotarsky, Victor Dahan, Arik |
author_facet | Lev, Shaul Snyder, David Azran, Carmil Zolotarsky, Victor Dahan, Arik |
author_sort | Lev, Shaul |
collection | PubMed |
description | Colchicine overdose is uncommon but potentially life threatening. Due to its serious adverse systemic effects, overdose must be recognized and treated. We report a case of an 18-year-old female who ingested 18 mg (~0.4 mg/kg) of colchicine in a suicide attempt. The patient’s clinical manifestations included abdominal cramps, vomiting, pancytopenia, hypocholesterolemia, and rhabdomyolysis. Two unique manifestations of toxicity in this patient were profound and persistent, severe hypertriglyceridemia and electrolyte imbalance, mainly hypophosphatemia, with no other evident cause except the colchicine intoxication. Following intensive supportive treatment, including ventilator support, N-acetylcysteine, granulocyte colony stimulating factor, electrolyte repletion, and zinc supplementation, the patient made a complete recovery. Colchicine intoxication is a severe, life-threatening situation that should be followed closely in intensive care units. Severe changes in body functions can rapidly develop, as previously described in the literature. To our knowledge, this extremely elevated triglyceride level has never been reported without the administration of propofol, and requires further evaluation. |
format | Online Article Text |
id | pubmed-5702170 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-57021702017-11-30 Severe hypertriglyceridemia and colchicine intoxication following suicide attempt Lev, Shaul Snyder, David Azran, Carmil Zolotarsky, Victor Dahan, Arik Drug Des Devel Ther Case Report Colchicine overdose is uncommon but potentially life threatening. Due to its serious adverse systemic effects, overdose must be recognized and treated. We report a case of an 18-year-old female who ingested 18 mg (~0.4 mg/kg) of colchicine in a suicide attempt. The patient’s clinical manifestations included abdominal cramps, vomiting, pancytopenia, hypocholesterolemia, and rhabdomyolysis. Two unique manifestations of toxicity in this patient were profound and persistent, severe hypertriglyceridemia and electrolyte imbalance, mainly hypophosphatemia, with no other evident cause except the colchicine intoxication. Following intensive supportive treatment, including ventilator support, N-acetylcysteine, granulocyte colony stimulating factor, electrolyte repletion, and zinc supplementation, the patient made a complete recovery. Colchicine intoxication is a severe, life-threatening situation that should be followed closely in intensive care units. Severe changes in body functions can rapidly develop, as previously described in the literature. To our knowledge, this extremely elevated triglyceride level has never been reported without the administration of propofol, and requires further evaluation. Dove Medical Press 2017-11-22 /pmc/articles/PMC5702170/ /pubmed/29200827 http://dx.doi.org/10.2147/DDDT.S140574 Text en © 2017 Lev et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Case Report Lev, Shaul Snyder, David Azran, Carmil Zolotarsky, Victor Dahan, Arik Severe hypertriglyceridemia and colchicine intoxication following suicide attempt |
title | Severe hypertriglyceridemia and colchicine intoxication following suicide attempt |
title_full | Severe hypertriglyceridemia and colchicine intoxication following suicide attempt |
title_fullStr | Severe hypertriglyceridemia and colchicine intoxication following suicide attempt |
title_full_unstemmed | Severe hypertriglyceridemia and colchicine intoxication following suicide attempt |
title_short | Severe hypertriglyceridemia and colchicine intoxication following suicide attempt |
title_sort | severe hypertriglyceridemia and colchicine intoxication following suicide attempt |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702170/ https://www.ncbi.nlm.nih.gov/pubmed/29200827 http://dx.doi.org/10.2147/DDDT.S140574 |
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