Genetic deletion or pharmacological inhibition of soluble epoxide hydrolase reduces brain damage and attenuates neuroinflammation after intracerebral hemorrhage

BACKGROUND: Inflammatory responses significantly contribute to neuronal damage and poor functional outcomes following intracerebral hemorrhage (ICH). Soluble epoxide hydrolase (sEH) is known to induce neuroinflammatory responses via degradation of anti-inflammatory epoxyeicosatrienoic acids (EET), a...

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Detalles Bibliográficos
Autores principales: Wu, Chun-Hu, Shyue, Song-Kun, Hung, Tai-Ho, Wen, Shin, Lin, Chao-Chang, Chang, Che-Feng, Chen, Szu-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702198/
https://www.ncbi.nlm.nih.gov/pubmed/29178914
http://dx.doi.org/10.1186/s12974-017-1005-4

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