Novel antibiotic combinations proposed for treatment of Burkholderia cepacia complex infections

Effective strategies to manage Burkholderia cepacia complex (Bcc) infections in cystic fibrosis (CF) patients are lacking. We tested combinations of clinically available antibiotics and show that moxifloxacin-ceftazidime could inhibit 16 Bcc clinical isolates at physiologically achievable concentrat...

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Autores principales: El-Halfawy, Omar M., Naguib, Marwa M., Valvano, Miguel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702217/
https://www.ncbi.nlm.nih.gov/pubmed/29204272
http://dx.doi.org/10.1186/s13756-017-0279-8
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author El-Halfawy, Omar M.
Naguib, Marwa M.
Valvano, Miguel A.
author_facet El-Halfawy, Omar M.
Naguib, Marwa M.
Valvano, Miguel A.
author_sort El-Halfawy, Omar M.
collection PubMed
description Effective strategies to manage Burkholderia cepacia complex (Bcc) infections in cystic fibrosis (CF) patients are lacking. We tested combinations of clinically available antibiotics and show that moxifloxacin-ceftazidime could inhibit 16 Bcc clinical isolates at physiologically achievable concentrations. Adding low dose of colistin improved the efficacy of the combo, especially at conditions mimicking CF respiratory secretions.
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spelling pubmed-57022172017-12-04 Novel antibiotic combinations proposed for treatment of Burkholderia cepacia complex infections El-Halfawy, Omar M. Naguib, Marwa M. Valvano, Miguel A. Antimicrob Resist Infect Control Short Report Effective strategies to manage Burkholderia cepacia complex (Bcc) infections in cystic fibrosis (CF) patients are lacking. We tested combinations of clinically available antibiotics and show that moxifloxacin-ceftazidime could inhibit 16 Bcc clinical isolates at physiologically achievable concentrations. Adding low dose of colistin improved the efficacy of the combo, especially at conditions mimicking CF respiratory secretions. BioMed Central 2017-11-25 /pmc/articles/PMC5702217/ /pubmed/29204272 http://dx.doi.org/10.1186/s13756-017-0279-8 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
El-Halfawy, Omar M.
Naguib, Marwa M.
Valvano, Miguel A.
Novel antibiotic combinations proposed for treatment of Burkholderia cepacia complex infections
title Novel antibiotic combinations proposed for treatment of Burkholderia cepacia complex infections
title_full Novel antibiotic combinations proposed for treatment of Burkholderia cepacia complex infections
title_fullStr Novel antibiotic combinations proposed for treatment of Burkholderia cepacia complex infections
title_full_unstemmed Novel antibiotic combinations proposed for treatment of Burkholderia cepacia complex infections
title_short Novel antibiotic combinations proposed for treatment of Burkholderia cepacia complex infections
title_sort novel antibiotic combinations proposed for treatment of burkholderia cepacia complex infections
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702217/
https://www.ncbi.nlm.nih.gov/pubmed/29204272
http://dx.doi.org/10.1186/s13756-017-0279-8
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