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Development of All India Institute of Medical Sciences-Modified International Clinical Epidemiology Network Diagnostic Instrument for Neuromotor Impairments in Children Aged 1 Month to 18 Years
INTRODUCTION: There is shortage of specialists for the diagnosis of children with neuromotor impairments (NMIs), especially in resource limited settings. Existing International Clinical Epidemiology Network (INCLEN) instrument for diagnosing NMI have been validated for children aged 2–9 years. The c...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702309/ https://www.ncbi.nlm.nih.gov/pubmed/29209604 http://dx.doi.org/10.3389/fpubh.2017.00313 |
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author | Gulati, Sheffali Patel, Harsh Chakrabarty, Biswaroop Dubey, Rachana Arora, N. K. Pandey, R. M. Paul, Vinod K. Ramesh, Konanki Anand, Vyshakh Meena, Ankit |
author_facet | Gulati, Sheffali Patel, Harsh Chakrabarty, Biswaroop Dubey, Rachana Arora, N. K. Pandey, R. M. Paul, Vinod K. Ramesh, Konanki Anand, Vyshakh Meena, Ankit |
author_sort | Gulati, Sheffali |
collection | PubMed |
description | INTRODUCTION: There is shortage of specialists for the diagnosis of children with neuromotor impairments (NMIs), especially in resource limited settings. Existing International Clinical Epidemiology Network (INCLEN) instrument for diagnosing NMI have been validated for children aged 2–9 years. The current study modified the same including wider symptomatology and age group (1 month to 18 years). METHODS: The Modified INCLEN diagnostic tool (INDT) was developed by a team of experts by modifying the existing tool to widen the age range (1 month to 18 years) and include broader symptomatology (inclusion of milestones from the first 2 years of life and better elucidation of cerebellar and extrapyramidal features) in a tertiary care teaching hospital of North India between January and April 2015. A trained medical graduate applied the candidate tool, which was followed by gold standard evaluation by a Pediatric Neurologist (both blinded to each other). RESULTS: A total of 197 children (102 with NMI and 95 without NMI) were enrolled for the study. The sensitivity, specificity, positive and negative predictive values, positive and negative likelihood ratio of the modified NMI tool were 90.4% (82.6–95.5), 95.5% (88.7–98.7), 95.5% (88.9–98.7), 90.3% (82.4–95.5), 19.9 (12.1–32.6), and 0.13 (0.08–0.12), respectively. CONCLUSION: The All India Institute of Medical Sciences modified INDT NMI tool is a simple and structured instrument covering a wider symptomatology in the 1 month to 18 years age group with acceptable diagnostic accuracy. |
format | Online Article Text |
id | pubmed-5702309 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-57023092017-12-05 Development of All India Institute of Medical Sciences-Modified International Clinical Epidemiology Network Diagnostic Instrument for Neuromotor Impairments in Children Aged 1 Month to 18 Years Gulati, Sheffali Patel, Harsh Chakrabarty, Biswaroop Dubey, Rachana Arora, N. K. Pandey, R. M. Paul, Vinod K. Ramesh, Konanki Anand, Vyshakh Meena, Ankit Front Public Health Public Health INTRODUCTION: There is shortage of specialists for the diagnosis of children with neuromotor impairments (NMIs), especially in resource limited settings. Existing International Clinical Epidemiology Network (INCLEN) instrument for diagnosing NMI have been validated for children aged 2–9 years. The current study modified the same including wider symptomatology and age group (1 month to 18 years). METHODS: The Modified INCLEN diagnostic tool (INDT) was developed by a team of experts by modifying the existing tool to widen the age range (1 month to 18 years) and include broader symptomatology (inclusion of milestones from the first 2 years of life and better elucidation of cerebellar and extrapyramidal features) in a tertiary care teaching hospital of North India between January and April 2015. A trained medical graduate applied the candidate tool, which was followed by gold standard evaluation by a Pediatric Neurologist (both blinded to each other). RESULTS: A total of 197 children (102 with NMI and 95 without NMI) were enrolled for the study. The sensitivity, specificity, positive and negative predictive values, positive and negative likelihood ratio of the modified NMI tool were 90.4% (82.6–95.5), 95.5% (88.7–98.7), 95.5% (88.9–98.7), 90.3% (82.4–95.5), 19.9 (12.1–32.6), and 0.13 (0.08–0.12), respectively. CONCLUSION: The All India Institute of Medical Sciences modified INDT NMI tool is a simple and structured instrument covering a wider symptomatology in the 1 month to 18 years age group with acceptable diagnostic accuracy. Frontiers Media S.A. 2017-11-21 /pmc/articles/PMC5702309/ /pubmed/29209604 http://dx.doi.org/10.3389/fpubh.2017.00313 Text en Copyright © 2017 Gulati, Patel, Chakrabarty, Dubey, Arora, Pandey, Paul, Ramesh, Anand and Meena. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Public Health Gulati, Sheffali Patel, Harsh Chakrabarty, Biswaroop Dubey, Rachana Arora, N. K. Pandey, R. M. Paul, Vinod K. Ramesh, Konanki Anand, Vyshakh Meena, Ankit Development of All India Institute of Medical Sciences-Modified International Clinical Epidemiology Network Diagnostic Instrument for Neuromotor Impairments in Children Aged 1 Month to 18 Years |
title | Development of All India Institute of Medical Sciences-Modified International Clinical Epidemiology Network Diagnostic Instrument for Neuromotor Impairments in Children Aged 1 Month to 18 Years |
title_full | Development of All India Institute of Medical Sciences-Modified International Clinical Epidemiology Network Diagnostic Instrument for Neuromotor Impairments in Children Aged 1 Month to 18 Years |
title_fullStr | Development of All India Institute of Medical Sciences-Modified International Clinical Epidemiology Network Diagnostic Instrument for Neuromotor Impairments in Children Aged 1 Month to 18 Years |
title_full_unstemmed | Development of All India Institute of Medical Sciences-Modified International Clinical Epidemiology Network Diagnostic Instrument for Neuromotor Impairments in Children Aged 1 Month to 18 Years |
title_short | Development of All India Institute of Medical Sciences-Modified International Clinical Epidemiology Network Diagnostic Instrument for Neuromotor Impairments in Children Aged 1 Month to 18 Years |
title_sort | development of all india institute of medical sciences-modified international clinical epidemiology network diagnostic instrument for neuromotor impairments in children aged 1 month to 18 years |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702309/ https://www.ncbi.nlm.nih.gov/pubmed/29209604 http://dx.doi.org/10.3389/fpubh.2017.00313 |
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