Critical Role of Hepatic Cyp450s in the Testis-Specific Toxicity of (5R)-5-Hydroxytriptolide in C57BL/6 Mice

Low solubility, tissue accumulation, and toxicity are chief obstacles to developing triptolide derivatives, so a better understanding of the pharmacokinetics and toxicity of triptolide derivatives will help with these limitations. To address this, we studied pharmacokinetics and toxicity of (5R)-5-h...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Cunzhi, Li, Yu, Liu, Mingxia, Gao, Man, Li, Chenggang, Yan, Hong, Li, Chunzhu, Sun, Lihan, Mo, Liying, Wu, Chunyong, Qi, Xinming, Ren, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702336/
https://www.ncbi.nlm.nih.gov/pubmed/29209210
http://dx.doi.org/10.3389/fphar.2017.00832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702336/
https://www.ncbi.nlm.nih.gov/pubmed/29209210
http://dx.doi.org/10.3389/fphar.2017.00832

Ejemplares similares