Small Split Doses of CD34(+) Peripheral Blood Stem Cells to Support Repeated Cycles of Nonmyeloablative Chemotherapy

Cumulative myelosuppression is the main limiting factor for administration of repeated cycles of chemotherapy. We present a case series of five pediatric patients with high-risk solid malignancies who received small split peripheral blood stem cells (PBSC) doses of less than 1 × 10(6)/kg CD34(+) cel...

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Autores principales: Yankelevich, Maxim, Savasan, Sureyya, Dolgopolov, Igor, Chu, Roland, Mentkevich, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702414/
https://www.ncbi.nlm.nih.gov/pubmed/29259833
http://dx.doi.org/10.1155/2017/4184879
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author Yankelevich, Maxim
Savasan, Sureyya
Dolgopolov, Igor
Chu, Roland
Mentkevich, George
author_facet Yankelevich, Maxim
Savasan, Sureyya
Dolgopolov, Igor
Chu, Roland
Mentkevich, George
author_sort Yankelevich, Maxim
collection PubMed
description Cumulative myelosuppression is the main limiting factor for administration of repeated cycles of chemotherapy. We present a case series of five pediatric patients with high-risk solid malignancies who received small split peripheral blood stem cells (PBSC) doses of less than 1 × 10(6)/kg CD34(+) cells obtained after a single leukapheresis procedure and given after repeated cycles of ICE (ifosfamide, carboplatin, and etoposide) chemotherapy. Mean duration to absolute neutrophil count (ANC) recovery to >1000/mm(3) and platelet recovery to >50 × 10(3)/mm(3) was 17.1 and 24.3 days. Using split doses of PBSC prevented prolonged neutropenia after repeated cycles of submyeloablative chemotherapy.
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spelling pubmed-57024142017-12-19 Small Split Doses of CD34(+) Peripheral Blood Stem Cells to Support Repeated Cycles of Nonmyeloablative Chemotherapy Yankelevich, Maxim Savasan, Sureyya Dolgopolov, Igor Chu, Roland Mentkevich, George Case Rep Oncol Med Case Report Cumulative myelosuppression is the main limiting factor for administration of repeated cycles of chemotherapy. We present a case series of five pediatric patients with high-risk solid malignancies who received small split peripheral blood stem cells (PBSC) doses of less than 1 × 10(6)/kg CD34(+) cells obtained after a single leukapheresis procedure and given after repeated cycles of ICE (ifosfamide, carboplatin, and etoposide) chemotherapy. Mean duration to absolute neutrophil count (ANC) recovery to >1000/mm(3) and platelet recovery to >50 × 10(3)/mm(3) was 17.1 and 24.3 days. Using split doses of PBSC prevented prolonged neutropenia after repeated cycles of submyeloablative chemotherapy. Hindawi 2017 2017-11-12 /pmc/articles/PMC5702414/ /pubmed/29259833 http://dx.doi.org/10.1155/2017/4184879 Text en Copyright © 2017 Maxim Yankelevich et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Yankelevich, Maxim
Savasan, Sureyya
Dolgopolov, Igor
Chu, Roland
Mentkevich, George
Small Split Doses of CD34(+) Peripheral Blood Stem Cells to Support Repeated Cycles of Nonmyeloablative Chemotherapy
title Small Split Doses of CD34(+) Peripheral Blood Stem Cells to Support Repeated Cycles of Nonmyeloablative Chemotherapy
title_full Small Split Doses of CD34(+) Peripheral Blood Stem Cells to Support Repeated Cycles of Nonmyeloablative Chemotherapy
title_fullStr Small Split Doses of CD34(+) Peripheral Blood Stem Cells to Support Repeated Cycles of Nonmyeloablative Chemotherapy
title_full_unstemmed Small Split Doses of CD34(+) Peripheral Blood Stem Cells to Support Repeated Cycles of Nonmyeloablative Chemotherapy
title_short Small Split Doses of CD34(+) Peripheral Blood Stem Cells to Support Repeated Cycles of Nonmyeloablative Chemotherapy
title_sort small split doses of cd34(+) peripheral blood stem cells to support repeated cycles of nonmyeloablative chemotherapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702414/
https://www.ncbi.nlm.nih.gov/pubmed/29259833
http://dx.doi.org/10.1155/2017/4184879
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