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Cognitive, Emotional, and Auto-Activation Dimensions of Apathy in Parkinson's Disease

Apathy is one of the most frequent non-motor manifestations in Parkinson's disease (PD) that can lead to a whole range of deleterious outcomes. In 2006, Levy and Dubois proposed a model that distinguishes three different apathy aetiologies in PD divided into three subtypes of disrupted processi...

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Autores principales: Del-Monte, Jonathan, Bayard, Sophie, Graziani, Pierluigi, Gély-Nargeot, Marie C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702439/
https://www.ncbi.nlm.nih.gov/pubmed/29209182
http://dx.doi.org/10.3389/fnbeh.2017.00230
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author Del-Monte, Jonathan
Bayard, Sophie
Graziani, Pierluigi
Gély-Nargeot, Marie C.
author_facet Del-Monte, Jonathan
Bayard, Sophie
Graziani, Pierluigi
Gély-Nargeot, Marie C.
author_sort Del-Monte, Jonathan
collection PubMed
description Apathy is one of the most frequent non-motor manifestations in Parkinson's disease (PD) that can lead to a whole range of deleterious outcomes. In 2006, Levy and Dubois proposed a model that distinguishes three different apathy aetiologies in PD divided into three subtypes of disrupted processing: “emotional-affective,” “cognitive,” and “auto-activation.” These three dimensions associated with dopamine depletion present in the pathology would lead to the emergence of apathy in PD. The aim of this mini-review was to describe and discuss studies that have explore links between apathy and the three subtypes of disrupted processing proposed by Levy and Dubois (2006) and as well as the links between these dimensions and dopamine depletion in Parkinson's disease. The lack of consensus regarding the emotional-affective correlates of apathy and the lack of evidence supporting the hypothesis of the auto-activation deficit, do not clearly confirm the validity of Levy and Dubois's model. Furthermore, the suggested association between dopaminergic depletion and apathy must also be clarified.
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spelling pubmed-57024392017-12-05 Cognitive, Emotional, and Auto-Activation Dimensions of Apathy in Parkinson's Disease Del-Monte, Jonathan Bayard, Sophie Graziani, Pierluigi Gély-Nargeot, Marie C. Front Behav Neurosci Neuroscience Apathy is one of the most frequent non-motor manifestations in Parkinson's disease (PD) that can lead to a whole range of deleterious outcomes. In 2006, Levy and Dubois proposed a model that distinguishes three different apathy aetiologies in PD divided into three subtypes of disrupted processing: “emotional-affective,” “cognitive,” and “auto-activation.” These three dimensions associated with dopamine depletion present in the pathology would lead to the emergence of apathy in PD. The aim of this mini-review was to describe and discuss studies that have explore links between apathy and the three subtypes of disrupted processing proposed by Levy and Dubois (2006) and as well as the links between these dimensions and dopamine depletion in Parkinson's disease. The lack of consensus regarding the emotional-affective correlates of apathy and the lack of evidence supporting the hypothesis of the auto-activation deficit, do not clearly confirm the validity of Levy and Dubois's model. Furthermore, the suggested association between dopaminergic depletion and apathy must also be clarified. Frontiers Media S.A. 2017-11-21 /pmc/articles/PMC5702439/ /pubmed/29209182 http://dx.doi.org/10.3389/fnbeh.2017.00230 Text en Copyright © 2017 Del-Monte, Bayard, Graziani and Gély-Nargeot. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Del-Monte, Jonathan
Bayard, Sophie
Graziani, Pierluigi
Gély-Nargeot, Marie C.
Cognitive, Emotional, and Auto-Activation Dimensions of Apathy in Parkinson's Disease
title Cognitive, Emotional, and Auto-Activation Dimensions of Apathy in Parkinson's Disease
title_full Cognitive, Emotional, and Auto-Activation Dimensions of Apathy in Parkinson's Disease
title_fullStr Cognitive, Emotional, and Auto-Activation Dimensions of Apathy in Parkinson's Disease
title_full_unstemmed Cognitive, Emotional, and Auto-Activation Dimensions of Apathy in Parkinson's Disease
title_short Cognitive, Emotional, and Auto-Activation Dimensions of Apathy in Parkinson's Disease
title_sort cognitive, emotional, and auto-activation dimensions of apathy in parkinson's disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702439/
https://www.ncbi.nlm.nih.gov/pubmed/29209182
http://dx.doi.org/10.3389/fnbeh.2017.00230
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