In Vivo Evaluation of Galla chinensis Solution in the Topical Treatment of Dermatophytosis

AIM: Dermatophytosis is one of the main fungal diseases in humans and animals all over the world. Galla chinensis, a traditional medicine, has various pharmacological effects. The goal of this study was to evaluate the treatment effect of Galla chinensis solution (GCS) on dermatophytosis-infected dogs (Microsporum canis, Microsporum gypseum, and Trichophyton mentagrophytes, resp.). METHODS: The treatment effects of GCS were evaluated by mycological cure rates and clinical score comprised of three indices, including inflammation, hair loss, and lesion scale. RESULTS: The results showed that, in the three models of dermatophytosis, GCS significantly (P < 0.05) improved skin lesions and fungal eradication. GCS (10% and 5%) had higher efficacy compared to the positive control (Tujingpi Tincture). The fungal eradication efficacy exceeds 85% after treatment with GCS (10%, 5%, and 2.5%) on day 14. CONCLUSION: The GCS has antidermatophytosis effect in dogs, which may be a candidate drug for the treatment of dermatophytosis.