Diabetes Mellitus and Alzheimer’s Disease: The Protection of Epigallocatechin-3-gallate in Streptozotocin Injection-Induced Models

Diabetes mellitus is considered as a risk factor of Alzheimer’s disease (AD), the front runner of neurodegenerative disorders. Streptozotocin (STZ) is a toxin for pancreatic β-cell, which can construct a model of insulin deficient diabetes through intraperitoneal or intravenous injection. A model ge...

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Autores principales: Jia, Jin-Jing, Zeng, Xian-Si, Song, Xin-Qiang, Zhang, Peng-Peng, Chen, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702501/
https://www.ncbi.nlm.nih.gov/pubmed/29209211
http://dx.doi.org/10.3389/fphar.2017.00834
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author Jia, Jin-Jing
Zeng, Xian-Si
Song, Xin-Qiang
Zhang, Peng-Peng
Chen, Lei
author_facet Jia, Jin-Jing
Zeng, Xian-Si
Song, Xin-Qiang
Zhang, Peng-Peng
Chen, Lei
author_sort Jia, Jin-Jing
collection PubMed
description Diabetes mellitus is considered as a risk factor of Alzheimer’s disease (AD), the front runner of neurodegenerative disorders. Streptozotocin (STZ) is a toxin for pancreatic β-cell, which can construct a model of insulin deficient diabetes through intraperitoneal or intravenous injection. A model generated by intracerebroventricular STZ (icv-STZ) also shows numerous aspects of sporadic AD. The protective roles of tea polyphenols epigallocatechin-3-gallate (EGCG) on both two diseases were researched by some scientists. This review highlights the link between diabetes and AD and recent studies on STZ injection-induced models, and also discusses the protection of EGCG to clarify its treatment in STZ-induced diabetes and AD.
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spelling pubmed-57025012017-12-05 Diabetes Mellitus and Alzheimer’s Disease: The Protection of Epigallocatechin-3-gallate in Streptozotocin Injection-Induced Models Jia, Jin-Jing Zeng, Xian-Si Song, Xin-Qiang Zhang, Peng-Peng Chen, Lei Front Pharmacol Pharmacology Diabetes mellitus is considered as a risk factor of Alzheimer’s disease (AD), the front runner of neurodegenerative disorders. Streptozotocin (STZ) is a toxin for pancreatic β-cell, which can construct a model of insulin deficient diabetes through intraperitoneal or intravenous injection. A model generated by intracerebroventricular STZ (icv-STZ) also shows numerous aspects of sporadic AD. The protective roles of tea polyphenols epigallocatechin-3-gallate (EGCG) on both two diseases were researched by some scientists. This review highlights the link between diabetes and AD and recent studies on STZ injection-induced models, and also discusses the protection of EGCG to clarify its treatment in STZ-induced diabetes and AD. Frontiers Media S.A. 2017-11-16 /pmc/articles/PMC5702501/ /pubmed/29209211 http://dx.doi.org/10.3389/fphar.2017.00834 Text en Copyright © 2017 Jia, Zeng, Song, Zhang and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Jia, Jin-Jing
Zeng, Xian-Si
Song, Xin-Qiang
Zhang, Peng-Peng
Chen, Lei
Diabetes Mellitus and Alzheimer’s Disease: The Protection of Epigallocatechin-3-gallate in Streptozotocin Injection-Induced Models
title Diabetes Mellitus and Alzheimer’s Disease: The Protection of Epigallocatechin-3-gallate in Streptozotocin Injection-Induced Models
title_full Diabetes Mellitus and Alzheimer’s Disease: The Protection of Epigallocatechin-3-gallate in Streptozotocin Injection-Induced Models
title_fullStr Diabetes Mellitus and Alzheimer’s Disease: The Protection of Epigallocatechin-3-gallate in Streptozotocin Injection-Induced Models
title_full_unstemmed Diabetes Mellitus and Alzheimer’s Disease: The Protection of Epigallocatechin-3-gallate in Streptozotocin Injection-Induced Models
title_short Diabetes Mellitus and Alzheimer’s Disease: The Protection of Epigallocatechin-3-gallate in Streptozotocin Injection-Induced Models
title_sort diabetes mellitus and alzheimer’s disease: the protection of epigallocatechin-3-gallate in streptozotocin injection-induced models
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702501/
https://www.ncbi.nlm.nih.gov/pubmed/29209211
http://dx.doi.org/10.3389/fphar.2017.00834
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