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Nonribosomal Peptides from Marine Microbes and Their Antimicrobial and Anticancer Potential

Marine environments are largely unexplored and can be a source of new molecules for the treatment of many diseases such as malaria, cancer, tuberculosis, HIV etc. The Marine environment is one of the untapped bioresource of getting pharmacologically active nonribosomal peptides (NRPs). Bioprospectin...

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Autores principales: Agrawal, Shivankar, Acharya, Debabrata, Adholeya, Alok, Barrow, Colin J., Deshmukh, Sunil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702503/
https://www.ncbi.nlm.nih.gov/pubmed/29209209
http://dx.doi.org/10.3389/fphar.2017.00828
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author Agrawal, Shivankar
Acharya, Debabrata
Adholeya, Alok
Barrow, Colin J.
Deshmukh, Sunil K.
author_facet Agrawal, Shivankar
Acharya, Debabrata
Adholeya, Alok
Barrow, Colin J.
Deshmukh, Sunil K.
author_sort Agrawal, Shivankar
collection PubMed
description Marine environments are largely unexplored and can be a source of new molecules for the treatment of many diseases such as malaria, cancer, tuberculosis, HIV etc. The Marine environment is one of the untapped bioresource of getting pharmacologically active nonribosomal peptides (NRPs). Bioprospecting of marine microbes have achieved many remarkable milestones in pharmaceutics. Till date, more than 50% of drugs which are in clinical use belong to the nonribosomal peptide or mixed polyketide-nonribosomal peptide families of natural products isolated from marine bacteria, cyanobacteria and fungi. In recent years large numbers of nonribosomal have been discovered from marine microbes using multi-disciplinary approaches. The present review covers the NRPs discovered from marine microbes and their pharmacological potential along with role of genomics, proteomics and bioinformatics in discovery and development of nonribosomal peptides drugs.
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spelling pubmed-57025032017-12-05 Nonribosomal Peptides from Marine Microbes and Their Antimicrobial and Anticancer Potential Agrawal, Shivankar Acharya, Debabrata Adholeya, Alok Barrow, Colin J. Deshmukh, Sunil K. Front Pharmacol Pharmacology Marine environments are largely unexplored and can be a source of new molecules for the treatment of many diseases such as malaria, cancer, tuberculosis, HIV etc. The Marine environment is one of the untapped bioresource of getting pharmacologically active nonribosomal peptides (NRPs). Bioprospecting of marine microbes have achieved many remarkable milestones in pharmaceutics. Till date, more than 50% of drugs which are in clinical use belong to the nonribosomal peptide or mixed polyketide-nonribosomal peptide families of natural products isolated from marine bacteria, cyanobacteria and fungi. In recent years large numbers of nonribosomal have been discovered from marine microbes using multi-disciplinary approaches. The present review covers the NRPs discovered from marine microbes and their pharmacological potential along with role of genomics, proteomics and bioinformatics in discovery and development of nonribosomal peptides drugs. Frontiers Media S.A. 2017-11-21 /pmc/articles/PMC5702503/ /pubmed/29209209 http://dx.doi.org/10.3389/fphar.2017.00828 Text en Copyright © 2017 Agrawal, Acharya, Adholeya, Barrow and Deshmukh. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Agrawal, Shivankar
Acharya, Debabrata
Adholeya, Alok
Barrow, Colin J.
Deshmukh, Sunil K.
Nonribosomal Peptides from Marine Microbes and Their Antimicrobial and Anticancer Potential
title Nonribosomal Peptides from Marine Microbes and Their Antimicrobial and Anticancer Potential
title_full Nonribosomal Peptides from Marine Microbes and Their Antimicrobial and Anticancer Potential
title_fullStr Nonribosomal Peptides from Marine Microbes and Their Antimicrobial and Anticancer Potential
title_full_unstemmed Nonribosomal Peptides from Marine Microbes and Their Antimicrobial and Anticancer Potential
title_short Nonribosomal Peptides from Marine Microbes and Their Antimicrobial and Anticancer Potential
title_sort nonribosomal peptides from marine microbes and their antimicrobial and anticancer potential
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702503/
https://www.ncbi.nlm.nih.gov/pubmed/29209209
http://dx.doi.org/10.3389/fphar.2017.00828
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