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Concise Review: Induced Pluripotent Stem Cell Models for Neuropsychiatric Diseases

The major neuropsychiatric conditions of schizophrenia, affective disorders, and infantile autism are characterized by chronic symptoms of episodic, stable, or progressive nature that result in significant morbidity. Symptomatic treatments are the mainstay but do not resolve the underlying disease p...

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Autores principales: Adegbola, Abidemi, Bury, Luke A., Fu, Chen, Zhang, Meixiang, Wynshaw‐Boris, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702513/
https://www.ncbi.nlm.nih.gov/pubmed/29027744
http://dx.doi.org/10.1002/sctm.17-0150
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author Adegbola, Abidemi
Bury, Luke A.
Fu, Chen
Zhang, Meixiang
Wynshaw‐Boris, Anthony
author_facet Adegbola, Abidemi
Bury, Luke A.
Fu, Chen
Zhang, Meixiang
Wynshaw‐Boris, Anthony
author_sort Adegbola, Abidemi
collection PubMed
description The major neuropsychiatric conditions of schizophrenia, affective disorders, and infantile autism are characterized by chronic symptoms of episodic, stable, or progressive nature that result in significant morbidity. Symptomatic treatments are the mainstay but do not resolve the underlying disease processes, which are themselves poorly understood. The prototype psychotropic drugs are of variable efficacy, with therapeutic mechanisms of action that are still uncertain. Thus, neuropsychiatric disorders are ripe for new technologies and approaches with the potential to revolutionize mechanistic understanding and drive the development of novel targeted treatments. The advent of methods to produce patient‐derived stem cell models and three‐dimensional organoids with the capacity to differentiate into neurons and the various neuronal cellular lineages mark such an advance. We discuss numerous techniques involved, their applications, and areas that require further optimization. Stem Cells Translational Medicine 2017;6:2062–2070
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spelling pubmed-57025132017-11-30 Concise Review: Induced Pluripotent Stem Cell Models for Neuropsychiatric Diseases Adegbola, Abidemi Bury, Luke A. Fu, Chen Zhang, Meixiang Wynshaw‐Boris, Anthony Stem Cells Transl Med Translational Research Articles and Reviews The major neuropsychiatric conditions of schizophrenia, affective disorders, and infantile autism are characterized by chronic symptoms of episodic, stable, or progressive nature that result in significant morbidity. Symptomatic treatments are the mainstay but do not resolve the underlying disease processes, which are themselves poorly understood. The prototype psychotropic drugs are of variable efficacy, with therapeutic mechanisms of action that are still uncertain. Thus, neuropsychiatric disorders are ripe for new technologies and approaches with the potential to revolutionize mechanistic understanding and drive the development of novel targeted treatments. The advent of methods to produce patient‐derived stem cell models and three‐dimensional organoids with the capacity to differentiate into neurons and the various neuronal cellular lineages mark such an advance. We discuss numerous techniques involved, their applications, and areas that require further optimization. Stem Cells Translational Medicine 2017;6:2062–2070 John Wiley and Sons Inc. 2017-10-13 /pmc/articles/PMC5702513/ /pubmed/29027744 http://dx.doi.org/10.1002/sctm.17-0150 Text en © 2017 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Translational Research Articles and Reviews
Adegbola, Abidemi
Bury, Luke A.
Fu, Chen
Zhang, Meixiang
Wynshaw‐Boris, Anthony
Concise Review: Induced Pluripotent Stem Cell Models for Neuropsychiatric Diseases
title Concise Review: Induced Pluripotent Stem Cell Models for Neuropsychiatric Diseases
title_full Concise Review: Induced Pluripotent Stem Cell Models for Neuropsychiatric Diseases
title_fullStr Concise Review: Induced Pluripotent Stem Cell Models for Neuropsychiatric Diseases
title_full_unstemmed Concise Review: Induced Pluripotent Stem Cell Models for Neuropsychiatric Diseases
title_short Concise Review: Induced Pluripotent Stem Cell Models for Neuropsychiatric Diseases
title_sort concise review: induced pluripotent stem cell models for neuropsychiatric diseases
topic Translational Research Articles and Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702513/
https://www.ncbi.nlm.nih.gov/pubmed/29027744
http://dx.doi.org/10.1002/sctm.17-0150
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