Insight into partial agonism by observing multiple equilibria for ligand-bound and G(s)-mimetic nanobody-bound β(1)-adrenergic receptor

A complex conformational energy landscape determines G-protein-coupled receptor (GPCR) signalling via intracellular binding partners (IBPs), e.g., G(s) and β-arrestin. Using (13)C methyl methionine NMR for the β(1)-adrenergic receptor, we identify ligand efficacy-dependent equilibria between an inac...

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Detalles Bibliográficos
Autores principales: Solt, Andras S., Bostock, Mark J., Shrestha, Binesh, Kumar, Prashant, Warne, Tony, Tate, Christopher G., Nietlispach, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702606/
https://www.ncbi.nlm.nih.gov/pubmed/29176642
http://dx.doi.org/10.1038/s41467-017-02008-y

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