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T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes
Defects in T cell receptor (TCR) repertoire are proposed to predispose to autoimmunity. Here we show, by analyzing >2 × 10(8) TCRB sequences of circulating naive, central memory, regulatory and stem cell-like memory CD4(+) T cell subsets from patients with type 1 diabetes and healthy donors, that...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702608/ https://www.ncbi.nlm.nih.gov/pubmed/29176645 http://dx.doi.org/10.1038/s41467-017-01925-2 |