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Host Responses to Malassezia spp. in the Mammalian Skin
The skin of mammalian organisms is home for a myriad of microbes. Many of these commensals are thought to have beneficial effects on the host by critically contributing to immune homeostasis. Consequently, dysbiosis can have detrimental effects for the host that may manifest with inflammatory diseas...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702624/ https://www.ncbi.nlm.nih.gov/pubmed/29213272 http://dx.doi.org/10.3389/fimmu.2017.01614 |
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author | Sparber, Florian LeibundGut-Landmann, Salomé |
author_facet | Sparber, Florian LeibundGut-Landmann, Salomé |
author_sort | Sparber, Florian |
collection | PubMed |
description | The skin of mammalian organisms is home for a myriad of microbes. Many of these commensals are thought to have beneficial effects on the host by critically contributing to immune homeostasis. Consequently, dysbiosis can have detrimental effects for the host that may manifest with inflammatory diseases at the barrier tissue. Besides bacteria, fungi make an important contribution to the microbiota and among these, the yeast Malassezia widely dominates in most areas of the skin in healthy individuals. There is accumulating evidence that Malassezia spp. are involved in a variety of skin disorders in humans ranging from non- or mildly inflammatory conditions such as dandruff and pityriasis versicolor to more severe inflammatory skin diseases like seborrheic eczema and atopic dermatitis. In addition, Malassezia is strongly linked to the development of dermatitis and otitis externa in dogs. However, the association of Malassezia spp. with such diseases remains poorly characterized. Until now, studies on the fungus–host interaction remain sparse and they are mostly limited to experiments with isolated host cells in vitro. They suggest a multifaceted crosstalk of Malassezia spp. with the skin by direct activation of the host via conserved pattern recognition receptors and indirectly via the release of fungus-derived metabolites that can modulate the function of hematopoietic and/or non-hematopoietic cells in the barrier tissue. In this review, we discuss our current understanding of the host response to Malassezia spp. in the mammalian skin. |
format | Online Article Text |
id | pubmed-5702624 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-57026242017-12-06 Host Responses to Malassezia spp. in the Mammalian Skin Sparber, Florian LeibundGut-Landmann, Salomé Front Immunol Immunology The skin of mammalian organisms is home for a myriad of microbes. Many of these commensals are thought to have beneficial effects on the host by critically contributing to immune homeostasis. Consequently, dysbiosis can have detrimental effects for the host that may manifest with inflammatory diseases at the barrier tissue. Besides bacteria, fungi make an important contribution to the microbiota and among these, the yeast Malassezia widely dominates in most areas of the skin in healthy individuals. There is accumulating evidence that Malassezia spp. are involved in a variety of skin disorders in humans ranging from non- or mildly inflammatory conditions such as dandruff and pityriasis versicolor to more severe inflammatory skin diseases like seborrheic eczema and atopic dermatitis. In addition, Malassezia is strongly linked to the development of dermatitis and otitis externa in dogs. However, the association of Malassezia spp. with such diseases remains poorly characterized. Until now, studies on the fungus–host interaction remain sparse and they are mostly limited to experiments with isolated host cells in vitro. They suggest a multifaceted crosstalk of Malassezia spp. with the skin by direct activation of the host via conserved pattern recognition receptors and indirectly via the release of fungus-derived metabolites that can modulate the function of hematopoietic and/or non-hematopoietic cells in the barrier tissue. In this review, we discuss our current understanding of the host response to Malassezia spp. in the mammalian skin. Frontiers Media S.A. 2017-11-22 /pmc/articles/PMC5702624/ /pubmed/29213272 http://dx.doi.org/10.3389/fimmu.2017.01614 Text en Copyright © 2017 Sparber and LeibundGut-Landmann. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Sparber, Florian LeibundGut-Landmann, Salomé Host Responses to Malassezia spp. in the Mammalian Skin |
title | Host Responses to Malassezia spp. in the Mammalian Skin |
title_full | Host Responses to Malassezia spp. in the Mammalian Skin |
title_fullStr | Host Responses to Malassezia spp. in the Mammalian Skin |
title_full_unstemmed | Host Responses to Malassezia spp. in the Mammalian Skin |
title_short | Host Responses to Malassezia spp. in the Mammalian Skin |
title_sort | host responses to malassezia spp. in the mammalian skin |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702624/ https://www.ncbi.nlm.nih.gov/pubmed/29213272 http://dx.doi.org/10.3389/fimmu.2017.01614 |
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