The PDGFRα-laminin B1-keratin 19 cascade drives tumor progression at the invasive front of human hepatocellular carcinoma

Human hepatocellular carcinomas (HCCs) expressing the biliary/hepatic progenitor cell marker keratin 19 (K19) have been linked with a poor prognosis and exhibit an increase in platelet-derived growth factor receptor α (PDGFRα) and laminin beta 1 (LAMB1) expression. PDGFRα has been reported to induce...

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Detalles Bibliográficos
Autores principales: Govaere, O, Petz, M, Wouters, J, Vandewynckel, Y-P, Scott, E J, Topal, B, Nevens, F, Verslype, C, Anstee, Q M, Van Vlierberghe, H, Mikulits, W, Roskams, T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702717/
https://www.ncbi.nlm.nih.gov/pubmed/28783171
http://dx.doi.org/10.1038/onc.2017.260

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