A randomized, exploratory molecular imaging study targeting amyloid β with a novel 8-OH quinoline in Alzheimer's disease: The PBT2-204 IMAGINE study

INTRODUCTION: We are developing a second generation 8-OH quinoline (2-(dimethylamino) methyl-5, 7-dichloro-8-hydroxyquinoline [PBT2, Prana Biotechnology]) for targeting amyloid β (Aβ) in Alzheimer's disease (AD). In an earlier phase IIa, 3 month trial, PBT2 lowered cerebrospinal fluid Aβ by 13%...

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Detalles Bibliográficos
Autores principales: Villemagne, Victor L., Rowe, Christopher C., Barnham, Kevin J., Cherny, Robert, Woodward, Michael, Bozinosvski, Svetlana, Salvado, Olivier, Bourgeat, Pierrick, Perez, Keyla, Fowler, Christopher, Rembach, Alan, Maruff, Paul, Ritchie, Craig, Tanzi, Rudy, Masters, Colin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702880/
https://www.ncbi.nlm.nih.gov/pubmed/29201996
http://dx.doi.org/10.1016/j.trci.2017.10.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702880/
https://www.ncbi.nlm.nih.gov/pubmed/29201996
http://dx.doi.org/10.1016/j.trci.2017.10.001

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