Cargando…

A randomized, exploratory molecular imaging study targeting amyloid β with a novel 8-OH quinoline in Alzheimer's disease: The PBT2-204 IMAGINE study

INTRODUCTION: We are developing a second generation 8-OH quinoline (2-(dimethylamino) methyl-5, 7-dichloro-8-hydroxyquinoline [PBT2, Prana Biotechnology]) for targeting amyloid β (Aβ) in Alzheimer's disease (AD). In an earlier phase IIa, 3 month trial, PBT2 lowered cerebrospinal fluid Aβ by 13%...

Descripción completa

Detalles Bibliográficos
Autores principales:	Villemagne, Victor L., Rowe, Christopher C., Barnham, Kevin J., Cherny, Robert, Woodward, Michael, Bozinosvski, Svetlana, Salvado, Olivier, Bourgeat, Pierrick, Perez, Keyla, Fowler, Christopher, Rembach, Alan, Maruff, Paul, Ritchie, Craig, Tanzi, Rudy, Masters, Colin L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Featured Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702880/ https://www.ncbi.nlm.nih.gov/pubmed/29201996 http://dx.doi.org/10.1016/j.trci.2017.10.001

Ejemplares similares

Sensitivity of composite scores to amyloid burden in preclinical Alzheimer's disease: Introducing the Z-scores of Attention, Verbal fluency, and Episodic memory for Nondemented older adults composite score
por: Lim, Yen Ying, et al.
Publicado: (2015)

Higher Coffee Consumption Is Associated With Slower Cognitive Decline and Less Cerebral Aβ-Amyloid Accumulation Over 126 Months: Data From the Australian Imaging, Biomarkers, and Lifestyle Study
por: Gardener, Samantha L., et al.
Publicado: (2021)

MR-Less Surface-Based Amyloid Assessment Based on (11)C PiB PET
por: Zhou, Luping, et al.
Publicado: (2014)

Bio-Based PBT–DLA Copolyester as an Alternative Compatibilizer of PP/PBT Blends
por: Ignaczak, Wojciech, et al.
Publicado: (2019)

The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease
por: Finkelstein, David I., et al.
Publicado: (2017)

Rates of regional tau accumulation in ageing and across the Alzheimer's disease continuum: an AIBL (18)F-MK6240 PET study
por: Krishnadas, Natasha, et al.
Publicado: (2023)

Correction to: The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease
por: Finkelstein, David I., et al.
Publicado: (2021)

Effect of BDNF Val66Met on Memory Decline and Hippocampal Atrophy in Prodromal Alzheimer’s Disease: A Preliminary Study
por: Lim, Yen Ying, et al.
Publicado: (2014)

Relationship between amyloid and tau levels and its impact on tau spreading
por: Doré, Vincent, et al.
Publicado: (2021)

Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume
por: Milicic, Lidija, et al.
Publicado: (2022)

Tribology of Polymer Blends PBT + PTFE
por: Georgescu, Constantin, et al.
Publicado: (2021)

Functionalization of Woven Fabrics with PBT Yarns
por: Kostajnšek, Klara, et al.
Publicado: (2021)

Visually Identified Tau (18)F-MK6240 PET Patterns in Symptomatic Alzheimer’s Disease
por: Krishnadas, Natasha, et al.
Publicado: (2022)

Multiple Bactericidal Mechanisms of the Zinc Ionophore PBT2
por: Harbison-Price, Nichaela, et al.
Publicado: (2020)

Using imputation to provide harmonized longitudinal measures of cognition across AIBL and ADNI
por: Shishegar, Rosita, et al.
Publicado: (2021)

Mesial temporal tau in amyloid-β-negative cognitively normal older persons
por: Krishnadas, Natasha, et al.
Publicado: (2022)

Association of β-Amyloid Level, Clinical Progression, and Longitudinal Cognitive Change in Normal Older Individuals
por: van der Kall, Laura M., et al.
Publicado: (2021)

Longitudinal Trajectories in Cortical Thickness and Volume Atrophy: Superior Cognitive Performance Does Not Protect Against Brain Atrophy in Older Adults
por: Gardener, Samantha L., et al.
Publicado: (2021)

Cerebrospinal fluid levels of fatty acid–binding protein 3 are associated with likelihood of amyloidopathy in cognitively healthy individuals
por: Dhiman, Kunal, et al.
Publicado: (2022)

A universal neocortical mask for Centiloid quantification
por: Bourgeat, Pierrick, et al.
Publicado: (2023)

KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4-positive cognitively normal adults with high Aβ-amyloid burden
por: Porter, Tenielle, et al.
Publicado: (2018)

Instruments and the imagination
por: Lawrence, Christopher
Publicado: (1997)

APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer's disease
por: Lim, Y Y, et al.
Publicado: (2015)

Networks and services: carrier ethernet, PBT, MPLS-TP and VPLS
por: Toy, Mehmet
Publicado: (2012)

Practical PBT/PC/GNP composites with anisotropic thermal conductivity
por: Zheng, Xiaolei, et al.
Publicado: (2019)

Temperature Responsive PBT Bicomponent Fibers for Dynamic Thermal Insulation
por: Khadse, Ninad, et al.
Publicado: (2022)

Cerebrospinal Fluid Neurofilament Light Predicts Risk of Dementia Onset in Cognitively Healthy Individuals and Rate of Cognitive Decline in Mild Cognitive Impairment: A Prospective Longitudinal Study
por: Dhiman, Kunal, et al.
Publicado: (2022)

Residual reserve index modifies the effect of amyloid pathology on fluorodeoxyglucose metabolism: Implications for efficiency and capacity in cognitive reserve
por: McKenzie, Cathryn, et al.
Publicado: (2022)

Decreased Copper in Alzheimer's Disease Brain Is Predominantly in the Soluble Extractable Fraction
por: Rembach, Alan, et al.
Publicado: (2013)

Chemical Synergy between Ionophore PBT2 and Zinc Reverses Antibiotic Resistance
por: Bohlmann, Lisa, et al.
Publicado: (2018)

Assessment of a polygenic hazard score for the onset of pre-clinical Alzheimer’s disease
por: Vacher, Michael, et al.
Publicado: (2022)

Insights into the Bead Fusion Mechanism of Expanded Polybutylene Terephthalate (E-PBT)
por: Kuhnigk, Justus, et al.
Publicado: (2021)

Effect of Thermal Aging on Mechanical Properties and Morphology of GF/PBT Composites
por: Xu, Xiuqi, et al.
Publicado: (2023)

Core Alzheimer’s disease cerebrospinal fluid biomarker assays are not affected by aspiration or gravity drip extraction methods
por: Doecke, James D., et al.
Publicado: (2021)

Plasma p‐tau181/Aβ(1‐42) ratio predicts Aβ‐PET status and correlates with CSF‐p‐tau181/Aβ(1‐42) and future cognitive decline
por: Fowler, Christopher J., et al.
Publicado: (2022)

PEOT/PBT Polymeric Pastes to Fabricate Additive Manufactured Scaffolds for Tissue Engineering
por: Higuera, Gustavo A., et al.
Publicado: (2021)

Redesign of the Geometry of Parts Produced from PBT Composite to Improve Their Operational Behavior
por: Dobrotă, Dan, et al.
Publicado: (2021)

Abrasion-Induced Acceleration of Melt Crystallisation of Wet Comminuted Polybutylene Terephthalate (PBT)
por: Tischer, Florentin, et al.
Publicado: (2022)

Neuropsychology and neuroimaging profiles of amyloid-positive versus amyloid-negative amnestic mild cognitive impairment patients
por: Tomadesso, Clémence, et al.
Publicado: (2018)

β-amyloid PET harmonisation across longitudinal studies: Application to AIBL, ADNI and OASIS3
por: Bourgeat, Pierrick, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_hlqfapg5hhkbjr9j1lddni2vm4