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Model‐Based Interspecies Scaling of Glucose Homeostasis

Being able to scale preclinical pharmacodynamic response to clinical would be beneficial in drug development. In this work, the integrated glucose insulin (IGI) model, developed on clinical intravenous glucose tolerance test (IVGTT) data, describing dynamic glucose and insulin concentrations during...

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Detalles Bibliográficos
Autores principales: Alskär, Oskar, Karlsson, Mats O., Kjellsson, Maria C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702901/
https://www.ncbi.nlm.nih.gov/pubmed/28960826
http://dx.doi.org/10.1002/psp4.12247