Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics

The scope of physiologically based pharmacokinetic (PBPK) modeling can be expanded by assimilation of the mechanistic models of intracellular processes from systems biology field. The genome scale metabolic networks (GSMNs) represent a whole set of metabolic enzymes expressed in human tissues. Dynam...

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Autores principales: Maldonado, Elaina M., Leoncikas, Vytautas, Fisher, Ciarán P., Moore, J. Bernadette, Plant, Nick J., Kierzek, Andrzej M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Tutorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702902/
https://www.ncbi.nlm.nih.gov/pubmed/28782239
http://dx.doi.org/10.1002/psp4.12230
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author Maldonado, Elaina M.
Leoncikas, Vytautas
Fisher, Ciarán P.
Moore, J. Bernadette
Plant, Nick J.
Kierzek, Andrzej M.
author_facet Maldonado, Elaina M.
Leoncikas, Vytautas
Fisher, Ciarán P.
Moore, J. Bernadette
Plant, Nick J.
Kierzek, Andrzej M.
author_sort Maldonado, Elaina M.
collection PubMed
description The scope of physiologically based pharmacokinetic (PBPK) modeling can be expanded by assimilation of the mechanistic models of intracellular processes from systems biology field. The genome scale metabolic networks (GSMNs) represent a whole set of metabolic enzymes expressed in human tissues. Dynamic models of the gene regulation of key drug metabolism enzymes are available. Here, we introduce GSMNs and review ongoing work on integration of PBPK, GSMNs, and metabolic gene regulation. We demonstrate example models.
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spelling pubmed-57029022017-11-29 Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics Maldonado, Elaina M. Leoncikas, Vytautas Fisher, Ciarán P. Moore, J. Bernadette Plant, Nick J. Kierzek, Andrzej M. CPT Pharmacometrics Syst Pharmacol Tutorial The scope of physiologically based pharmacokinetic (PBPK) modeling can be expanded by assimilation of the mechanistic models of intracellular processes from systems biology field. The genome scale metabolic networks (GSMNs) represent a whole set of metabolic enzymes expressed in human tissues. Dynamic models of the gene regulation of key drug metabolism enzymes are available. Here, we introduce GSMNs and review ongoing work on integration of PBPK, GSMNs, and metabolic gene regulation. We demonstrate example models. John Wiley and Sons Inc. 2017-09-08 2017-11 /pmc/articles/PMC5702902/ /pubmed/28782239 http://dx.doi.org/10.1002/psp4.12230 Text en © 2017 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Tutorial
Maldonado, Elaina M.
Leoncikas, Vytautas
Fisher, Ciarán P.
Moore, J. Bernadette
Plant, Nick J.
Kierzek, Andrzej M.
Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics
title Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics
title_full Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics
title_fullStr Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics
title_full_unstemmed Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics
title_short Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics
title_sort integration of genome scale metabolic networks and gene regulation of metabolic enzymes with physiologically based pharmacokinetics
topic Tutorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702902/
https://www.ncbi.nlm.nih.gov/pubmed/28782239
http://dx.doi.org/10.1002/psp4.12230
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