Predicting Drug Concentration‐Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically‐Based Pharmacokinetic Model

Drug development targeting the central nervous system (CNS) is challenging due to poor predictability of drug concentrations in various CNS compartments. We developed a generic physiologically based pharmacokinetic (PBPK) model for prediction of drug concentrations in physiologically relevant CNS co...

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Detalles Bibliográficos
Autores principales: Yamamoto, Yumi, Välitalo, Pyry A., Huntjens, Dymphy R., Proost, Johannes H., Vermeulen, An, Krauwinkel, Walter, Beukers, Margot W., van den Berg, Dirk‐Jan, Hartman, Robin, Wong, Yin Cheong, Danhof, Meindert, van Hasselt, John G. C., de Lange, Elizabeth C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702903/
https://www.ncbi.nlm.nih.gov/pubmed/28891201
http://dx.doi.org/10.1002/psp4.12250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702903/
https://www.ncbi.nlm.nih.gov/pubmed/28891201
http://dx.doi.org/10.1002/psp4.12250

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