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Ethnopharmacological Evaluation of Breu Essential Oils from Protium Species Administered by Inhalation

BACKGROUND: Breu is an aromatic oleoresin which has been used by Amazonian traditional communities as a remedy for headaches and migraines by burning and inhaling the smoke produced during its combustion. This study evaluated the antinociceptive and sedative activities of formulations containing bre...

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Autores principales: da Silva, Eduardo Rodrigues, de Oliveira, Danilo Ribeiro, Fernandes, Patrícia Dias, Bizzo, Humberto Ribeiro, Leitão, Suzana Guimarães
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702920/
https://www.ncbi.nlm.nih.gov/pubmed/29259642
http://dx.doi.org/10.1155/2017/2924171
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author da Silva, Eduardo Rodrigues
de Oliveira, Danilo Ribeiro
Fernandes, Patrícia Dias
Bizzo, Humberto Ribeiro
Leitão, Suzana Guimarães
author_facet da Silva, Eduardo Rodrigues
de Oliveira, Danilo Ribeiro
Fernandes, Patrícia Dias
Bizzo, Humberto Ribeiro
Leitão, Suzana Guimarães
author_sort da Silva, Eduardo Rodrigues
collection PubMed
description BACKGROUND: Breu is an aromatic oleoresin which has been used by Amazonian traditional communities as a remedy for headaches and migraines by burning and inhaling the smoke produced during its combustion. This study evaluated the antinociceptive and sedative activities of formulations containing breu essential oils administered by inhalation. METHODS: Five different formulations (A–E) containing breu essential oils were evaluated for their sedative and antinociceptive activities in mice. They were delivered for 20 minutes using an inhalation chamber coupled with a nebulizer and the air inside was collected by static headspace and analyzed by GC-FID. RESULTS: All nebulized formulations had similar chemical compositions and major compounds as the original essential oils. None of them resulted in significant increase in response time during the hot plate test. In the formalin test, Formulation E showed a significant inhibition of licking responses in the early (46.8%) and late (60.2%) phases. Formulation B was effective (36.9%) in the first phase and Formulation D (37.9%) in the second. None of the formulations presented sedative effects. CONCLUSION: Breu essential oils, when inhaled, may present antinociceptive and anti-inflammatory properties without sedation. Additionally, nebulization proved to be an efficient method for administration of formulations containing these essential oils.
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spelling pubmed-57029202017-12-19 Ethnopharmacological Evaluation of Breu Essential Oils from Protium Species Administered by Inhalation da Silva, Eduardo Rodrigues de Oliveira, Danilo Ribeiro Fernandes, Patrícia Dias Bizzo, Humberto Ribeiro Leitão, Suzana Guimarães Evid Based Complement Alternat Med Research Article BACKGROUND: Breu is an aromatic oleoresin which has been used by Amazonian traditional communities as a remedy for headaches and migraines by burning and inhaling the smoke produced during its combustion. This study evaluated the antinociceptive and sedative activities of formulations containing breu essential oils administered by inhalation. METHODS: Five different formulations (A–E) containing breu essential oils were evaluated for their sedative and antinociceptive activities in mice. They were delivered for 20 minutes using an inhalation chamber coupled with a nebulizer and the air inside was collected by static headspace and analyzed by GC-FID. RESULTS: All nebulized formulations had similar chemical compositions and major compounds as the original essential oils. None of them resulted in significant increase in response time during the hot plate test. In the formalin test, Formulation E showed a significant inhibition of licking responses in the early (46.8%) and late (60.2%) phases. Formulation B was effective (36.9%) in the first phase and Formulation D (37.9%) in the second. None of the formulations presented sedative effects. CONCLUSION: Breu essential oils, when inhaled, may present antinociceptive and anti-inflammatory properties without sedation. Additionally, nebulization proved to be an efficient method for administration of formulations containing these essential oils. Hindawi 2017 2017-11-13 /pmc/articles/PMC5702920/ /pubmed/29259642 http://dx.doi.org/10.1155/2017/2924171 Text en Copyright © 2017 Eduardo Rodrigues da Silva et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
da Silva, Eduardo Rodrigues
de Oliveira, Danilo Ribeiro
Fernandes, Patrícia Dias
Bizzo, Humberto Ribeiro
Leitão, Suzana Guimarães
Ethnopharmacological Evaluation of Breu Essential Oils from Protium Species Administered by Inhalation
title Ethnopharmacological Evaluation of Breu Essential Oils from Protium Species Administered by Inhalation
title_full Ethnopharmacological Evaluation of Breu Essential Oils from Protium Species Administered by Inhalation
title_fullStr Ethnopharmacological Evaluation of Breu Essential Oils from Protium Species Administered by Inhalation
title_full_unstemmed Ethnopharmacological Evaluation of Breu Essential Oils from Protium Species Administered by Inhalation
title_short Ethnopharmacological Evaluation of Breu Essential Oils from Protium Species Administered by Inhalation
title_sort ethnopharmacological evaluation of breu essential oils from protium species administered by inhalation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702920/
https://www.ncbi.nlm.nih.gov/pubmed/29259642
http://dx.doi.org/10.1155/2017/2924171
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