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Effects of Electrostatic Field on Osteoblast Cells for Bone Regeneration Applications

Many external stimulations have been shown to promote bone regeneration. The effects of an alternating current (AC) electrostatic field, one of external stimulations, generated from a device with high voltage and low current output on human osteoblastic cell line have been investigated in this study...

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Detalles Bibliográficos
Autores principales: Su, Chen-Ying, Fang, Tzan, Fang, Hsu-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702948/
https://www.ncbi.nlm.nih.gov/pubmed/29259985
http://dx.doi.org/10.1155/2017/7124817
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author Su, Chen-Ying
Fang, Tzan
Fang, Hsu-Wei
author_facet Su, Chen-Ying
Fang, Tzan
Fang, Hsu-Wei
author_sort Su, Chen-Ying
collection PubMed
description Many external stimulations have been shown to promote bone regeneration. The effects of an alternating current (AC) electrostatic field, one of external stimulations, generated from a device with high voltage and low current output on human osteoblastic cell line have been investigated in this study. We investigated how human osteoblasts responded to an AC electrostatic field, and the output parameters were set as 1 kV and 160 μA. Our results showed that, under such condition, the AC electrostatic field had a downregulation effect on the production ability of alkaline phosphatase and type 1 collagen expression. However, the expression of osteocalcin gene was elevated on the end of EFID treatment suggesting that AC electrostatic field might be a potential stimulation for accelerating the differentiation of osteoblastic cells.
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spelling pubmed-57029482017-12-19 Effects of Electrostatic Field on Osteoblast Cells for Bone Regeneration Applications Su, Chen-Ying Fang, Tzan Fang, Hsu-Wei Biomed Res Int Research Article Many external stimulations have been shown to promote bone regeneration. The effects of an alternating current (AC) electrostatic field, one of external stimulations, generated from a device with high voltage and low current output on human osteoblastic cell line have been investigated in this study. We investigated how human osteoblasts responded to an AC electrostatic field, and the output parameters were set as 1 kV and 160 μA. Our results showed that, under such condition, the AC electrostatic field had a downregulation effect on the production ability of alkaline phosphatase and type 1 collagen expression. However, the expression of osteocalcin gene was elevated on the end of EFID treatment suggesting that AC electrostatic field might be a potential stimulation for accelerating the differentiation of osteoblastic cells. Hindawi 2017 2017-11-13 /pmc/articles/PMC5702948/ /pubmed/29259985 http://dx.doi.org/10.1155/2017/7124817 Text en Copyright © 2017 Chen-Ying Su et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Su, Chen-Ying
Fang, Tzan
Fang, Hsu-Wei
Effects of Electrostatic Field on Osteoblast Cells for Bone Regeneration Applications
title Effects of Electrostatic Field on Osteoblast Cells for Bone Regeneration Applications
title_full Effects of Electrostatic Field on Osteoblast Cells for Bone Regeneration Applications
title_fullStr Effects of Electrostatic Field on Osteoblast Cells for Bone Regeneration Applications
title_full_unstemmed Effects of Electrostatic Field on Osteoblast Cells for Bone Regeneration Applications
title_short Effects of Electrostatic Field on Osteoblast Cells for Bone Regeneration Applications
title_sort effects of electrostatic field on osteoblast cells for bone regeneration applications
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702948/
https://www.ncbi.nlm.nih.gov/pubmed/29259985
http://dx.doi.org/10.1155/2017/7124817
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