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Effects of Electrostatic Field on Osteoblast Cells for Bone Regeneration Applications
Many external stimulations have been shown to promote bone regeneration. The effects of an alternating current (AC) electrostatic field, one of external stimulations, generated from a device with high voltage and low current output on human osteoblastic cell line have been investigated in this study...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702948/ https://www.ncbi.nlm.nih.gov/pubmed/29259985 http://dx.doi.org/10.1155/2017/7124817 |
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author | Su, Chen-Ying Fang, Tzan Fang, Hsu-Wei |
author_facet | Su, Chen-Ying Fang, Tzan Fang, Hsu-Wei |
author_sort | Su, Chen-Ying |
collection | PubMed |
description | Many external stimulations have been shown to promote bone regeneration. The effects of an alternating current (AC) electrostatic field, one of external stimulations, generated from a device with high voltage and low current output on human osteoblastic cell line have been investigated in this study. We investigated how human osteoblasts responded to an AC electrostatic field, and the output parameters were set as 1 kV and 160 μA. Our results showed that, under such condition, the AC electrostatic field had a downregulation effect on the production ability of alkaline phosphatase and type 1 collagen expression. However, the expression of osteocalcin gene was elevated on the end of EFID treatment suggesting that AC electrostatic field might be a potential stimulation for accelerating the differentiation of osteoblastic cells. |
format | Online Article Text |
id | pubmed-5702948 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-57029482017-12-19 Effects of Electrostatic Field on Osteoblast Cells for Bone Regeneration Applications Su, Chen-Ying Fang, Tzan Fang, Hsu-Wei Biomed Res Int Research Article Many external stimulations have been shown to promote bone regeneration. The effects of an alternating current (AC) electrostatic field, one of external stimulations, generated from a device with high voltage and low current output on human osteoblastic cell line have been investigated in this study. We investigated how human osteoblasts responded to an AC electrostatic field, and the output parameters were set as 1 kV and 160 μA. Our results showed that, under such condition, the AC electrostatic field had a downregulation effect on the production ability of alkaline phosphatase and type 1 collagen expression. However, the expression of osteocalcin gene was elevated on the end of EFID treatment suggesting that AC electrostatic field might be a potential stimulation for accelerating the differentiation of osteoblastic cells. Hindawi 2017 2017-11-13 /pmc/articles/PMC5702948/ /pubmed/29259985 http://dx.doi.org/10.1155/2017/7124817 Text en Copyright © 2017 Chen-Ying Su et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Su, Chen-Ying Fang, Tzan Fang, Hsu-Wei Effects of Electrostatic Field on Osteoblast Cells for Bone Regeneration Applications |
title | Effects of Electrostatic Field on Osteoblast Cells for Bone Regeneration Applications |
title_full | Effects of Electrostatic Field on Osteoblast Cells for Bone Regeneration Applications |
title_fullStr | Effects of Electrostatic Field on Osteoblast Cells for Bone Regeneration Applications |
title_full_unstemmed | Effects of Electrostatic Field on Osteoblast Cells for Bone Regeneration Applications |
title_short | Effects of Electrostatic Field on Osteoblast Cells for Bone Regeneration Applications |
title_sort | effects of electrostatic field on osteoblast cells for bone regeneration applications |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702948/ https://www.ncbi.nlm.nih.gov/pubmed/29259985 http://dx.doi.org/10.1155/2017/7124817 |
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