Cargando…

Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling

Bone morphogenetic protein receptor type 2 (BMPR2) mutations are present in patients with heritable and idiopathic pulmonary arterial hypertension (PAH). Circulating levels of interleukin-1 (IL-1) are raised in patients and animal models. Whether interplay between BMP and IL-1 signaling can explain...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pickworth, Josephine, Rothman, Alexander, Iremonger, James, Casbolt, Helen, Hopkinson, Kay, Hickey, Peter M., Gladson, Santhi, Shay, Sheila, Morrell, Nicholas W., Francis, Sheila E., West, James D., Lawrie, Allan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703124/ https://www.ncbi.nlm.nih.gov/pubmed/28828907 http://dx.doi.org/10.1177/2045893217729096

Ejemplares similares

Adverse effects of BMPR2 suppression in macrophages in animal models of pulmonary hypertension
por: West, James, et al.
Publicado: (2020)

rhACE2 Therapy Modifies Bleomycin-Induced Pulmonary Hypertension via Rescue of Vascular Remodeling
por: Rathinasabapathy, Anandharajan, et al.
Publicado: (2018)

BMPR2 expression is suppressed by signaling through the estrogen receptor
por: Austin, Eric D, et al.
Publicado: (2012)

Selective improvement of pulmonary arterial hypertension with a dual ET(A)/ET(B) receptors antagonist in the apolipoprotein E(−/−) model of PAH and atherosclerosis
por: Renshall, Lewis, et al.
Publicado: (2017)

Expression of a Human Caveolin-1 Mutation in Mice Drives Inflammatory and Metabolic Defect-Associated Pulmonary Arterial Hypertension
por: Rathinasabapathy, Anandharajan, et al.
Publicado: (2020)

Altered Macrophage Polarization Induces Experimental Pulmonary Hypertension and Is Observed in Patients With Pulmonary Arterial Hypertension
por: Zawia, Amira, et al.
Publicado: (2020)

A diagnostic miRNA signature for pulmonary arterial hypertension using a consensus machine learning approach
por: Errington, Niamh, et al.
Publicado: (2021)

Overexpression of Msx1 in Mouse Lung Leads to Loss of Pulmonary Vessels Following Vascular Hypoxic Injury
por: West, James, et al.
Publicado: (2021)

A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension
por: Arnold, Nadine D., et al.
Publicado: (2019)

A potential adverse role for leptin and cardiac leptin receptor in the right ventricle in pulmonary arterial hypertension: effect of metformin is BMPR2 mutation-specific
por: Talati, Megha, et al.
Publicado: (2023)

Serotonin 2B Receptor Antagonism Prevents Heritable Pulmonary Arterial Hypertension
por: West, James D., et al.
Publicado: (2016)

Serum osteoprotegerin is increased and predicts survival in idiopathic pulmonary arterial hypertension
por: Condliffe, Robin, et al.
Publicado: (2012)

Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension
por: Egnatchik, Robert A., et al.
Publicado: (2017)

Physiologic and molecular consequences of endothelial Bmpr2 mutation
por: Majka, Susan, et al.
Publicado: (2011)

The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations
por: Dunmore, Benjamin J., et al.
Publicado: (2013)

Molecular and functional characterization of the BMPR2 gene in Pulmonary Arterial Hypertension
por: Pousada, Guillermo, et al.
Publicado: (2017)

Copy-number variation in BMPR2 is not associated with the pathogenesis of pulmonary arterial hypertension
por: Johnson, Jennifer A, et al.
Publicado: (2009)

Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension
por: Boehm, Mario, et al.
Publicado: (2018)

Correction to: Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension
por: Boehm, Mario, et al.
Publicado: (2022)

Oxidative injury is a common consequence of BMPR2 mutations
por: Lane, Kirk L., et al.
Publicado: (2011)

Inhibition of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension
por: Hameed, Abdul G., et al.
Publicado: (2012)

The promise of recombinant BMP ligands and other approaches targeting BMPR-II in the treatment of pulmonary arterial hypertension
por: Ormiston, Mark L., et al.
Publicado: (2015)

Soluble P-Selectin and von Willebrand Factor Rise in Healthy Volunteers Following Non-exertional Ascent to High Altitude
por: Turton, Helena A., et al.
Publicado: (2022)

Homozygous missense variant in BMPR1A resulting in BMPR signaling disruption and syndromic features
por: Russell, Bianca E., et al.
Publicado: (2019)

The genetics of pulmonary arterial hypertension in the post-BMPR2 era
por: Fessel, Joshua P., et al.
Publicado: (2011)

Vildagliptin ameliorates pulmonary fibrosis in lipopolysaccharide-induced lung injury by inhibiting endothelial-to-mesenchymal transition
por: Suzuki, Toshio, et al.
Publicado: (2017)

Chronic Allergic Inflammation Causes Vascular Remodeling and Pulmonary Hypertension in Bmpr2 Hypomorph and Wild-Type Mice
por: Mushaben, Elizabeth M., et al.
Publicado: (2012)

Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2
por: Novoyatleva, Tatyana, et al.
Publicado: (2021)

Modification of Hemodynamic and Immune Responses to Exposure with a Weak Antigen by the Expression of a Hypomorphic BMPR2 Gene
por: Park, Sung-Hyun, et al.
Publicado: (2013)

Investigating the Polymorphism of Bone Morphogenetic Protein Receptor-1B (BMPR1B) Gene in Markhoz Goat Breed
por: Pourali Dogaheh, Sheila, et al.
Publicado: (2020)

Targeting translational read-through of premature termination mutations in BMPR2 with PTC124 for pulmonary arterial hypertension
por: Long, Lu, et al.
Publicado: (2020)

Hematopoietic stem cell transplantation alters susceptibility to pulmonary hypertension in Bmpr2-deficient mice
por: Crosby, Alexi, et al.
Publicado: (2018)

Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension
por: Long, Lu, et al.
Publicado: (2015)

BMPR2 Variants Underlie Nonsyndromic Oligodontia
por: Zheng, Jinglei, et al.
Publicado: (2023)

Endothelial BMPR2 Loss Drives a Proliferative Response to BMP (Bone Morphogenetic Protein) 9 via Prolonged Canonical Signaling
por: Theilmann, Anne L., et al.
Publicado: (2020)

Expression of mutant BMPR-II in pulmonary endothelial cells promotes apoptosis and a release of factors that stimulate proliferation of pulmonary arterial smooth muscle cells
por: Yang, Xudong, et al.
Publicado: (2011)

Pulmonary Vascular Platform Models the Effects of Flow and Pressure on Endothelial Dysfunction in BMPR2 Associated Pulmonary Arterial Hypertension
por: D’Amico, Reid W., et al.
Publicado: (2018)

Author Correction: Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2
por: Novoyatleva, Tatyana, et al.
Publicado: (2022)

IL-1 drives breast cancer growth and bone metastasis in vivo
por: Holen, Ingunn, et al.
Publicado: (2016)

Gene expression in BMPR2 mutation carriers with and without evidence of Pulmonary Arterial Hypertension suggests pathways relevant to disease penetrance
por: West, James, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_90lakmp8ff28ehaslr7tl5n9sk