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Synthesis and Demonstration of the Biological Relevance of sp(3)‐rich Scaffolds Distantly Related to Natural Product Frameworks

The productive exploration of chemical space is an enduring challenge in chemical biology and medicinal chemistry. Natural products are biologically relevant, and their frameworks have facilitated chemical tool and drug discovery. A “top‐down” synthetic approach is described that enabled a range of...

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Detalles Bibliográficos
Autores principales:	Foley, Daniel J., Craven, Philip G. E., Collins, Patrick M., Doveston, Richard G., Aimon, Anthony, Talon, Romain, Churcher, Ian, von Delft, Frank, Marsden, Stephen P., Nelson, Adam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703167/ https://www.ncbi.nlm.nih.gov/pubmed/28983993 http://dx.doi.org/10.1002/chem.201704169

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