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Safety testing of acellular pertussis vaccines: Use of animals and 3Rs alternatives
The current test of acellular Bordetella pertussis (aP) vaccines for residual pertussis toxin (PTx) is the Histamine Sensitization test (HIST), based on the empirical finding that PTx sensitizes mice to histamine. Although HIST has ensured the safety of aP vaccines for years, it is criticized for th...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703371/ https://www.ncbi.nlm.nih.gov/pubmed/28857652 http://dx.doi.org/10.1080/21645515.2017.1349585 |