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Vinorelbine in BRAF V600E mutated metastatic colorectal cancer: a prospective multicentre phase II clinical study

BACKGROUND: BRAF V600E mutation defines a specific colorectal cancer (CRC) subgroup with poor prognosis. Promising preclinical data showed synthetically lethal activity of mitotic spindle poisons on BRAF-mutated and BRAF-like CRC models. We designed a phase II trial to test the activity of vinorelbi...

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Detalles Bibliográficos
Autores principales:	Cremolini, Chiara, Pietrantonio, Filippo, Tomasello, Gianluca, Dadduzio, Vincenzo, Moretto, Roberto, Morano, Federica, Schirripa, Marta, Antoniotti, Carlotta, Fucà, Giovanni, Bergamo, Francesca, Rossini, Daniele, Nichetti, Federico, Ziampiri, Stamatia, Ghidini, Michele, Marmorino, Federica, Prisciandaro, Michele, Falcone, Alfredo, De Braud, Filippo, Loupakis, Fotios, Lonardi, Sara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703381/ https://www.ncbi.nlm.nih.gov/pubmed/29209533 http://dx.doi.org/10.1136/esmoopen-2017-000241

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