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Application of non-Gaussian water diffusional kurtosis imaging in the assessment of uterine tumors: A preliminary study
OBJECTIVES: To evaluate the interobserver reliability and value of diffusional kurtosis imaging (DKI) in the assessment of uterine tumors compared with those of conventional diffusion-weighted imaging (DWI). METHODS: This retrospective study was approved by our institutional review board, which waiv...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703480/ https://www.ncbi.nlm.nih.gov/pubmed/29176867 http://dx.doi.org/10.1371/journal.pone.0188434 |
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author | Dia, Aliou Amadou Hori, Masatoshi Onishi, Hiromitsu Sakane, Makoto Ota, Takashi Tsuboyama, Takahiro Tatsumi, Mitsuaki Okuaki, Tomoyuki Tomiyama, Noriyuki |
author_facet | Dia, Aliou Amadou Hori, Masatoshi Onishi, Hiromitsu Sakane, Makoto Ota, Takashi Tsuboyama, Takahiro Tatsumi, Mitsuaki Okuaki, Tomoyuki Tomiyama, Noriyuki |
author_sort | Dia, Aliou Amadou |
collection | PubMed |
description | OBJECTIVES: To evaluate the interobserver reliability and value of diffusional kurtosis imaging (DKI) in the assessment of uterine tumors compared with those of conventional diffusion-weighted imaging (DWI). METHODS: This retrospective study was approved by our institutional review board, which waived the requirement for informed consent. Fifty-eight women (mean age: 55.0 ± 13.6 years; range: 30–89 years) with suspected malignant uterine tumors underwent 3-T magnetic resonance imaging using DKI and DWI. Twelve had coexisting leiomyoma. Two observers analyzed region-of-interest measurements of diffusivity (D), kurtosis (K), and the apparent diffusion coefficient (ADC) of uterine lesions and healthy adjacent tissues. Interobserver agreement was evaluated using the intra-class correlation coefficient (ICC). The mean values were compared using one-way analysis of variance with a post-hoc Tukey’s honestly significant difference test. The diagnostic accuracy of D and ADC in differentiating malignant tumors from benign leiomyomas was analyzed using receiver operating characteristic (ROC) analysis. RESULTS: The ICCs between the two observers in evaluating D, K, and the ADC of the malignant tumors were higher than 0.84, suggesting excellent interobserver agreements. The mean D (×10(−3) mm(2)/s) of uterine cancers (1.05 ± 0.41 and 1.09 ± 0.40 for observers 1 and 2, respectively) were significantly lower than those of leiomyoma (1.40 ± 0.37 and 1.56 ± 0.33, respectively; P < 0.05), healthy myometrium (1.72 ± 0.27 and 1.69 ± 0.30, respectively; P < 0.001), and healthy endometrium (1.53 ± 0.35 and 1.42 ± 0.37, respectively; P < 0.005). There was no significant difference in the area under the ROC curve between D and ADC. The mean K of uterine cancers (0.88 ± 0.28 and 0.90 ± 0.23, respectively) were higher than those of myometrium (0.72 ± 0.10 and 0.73 ± 0.10, respectively; P < 0.001), healthy endometrium (0.65 ± 0.13 and 0.60 ± 0.18, respectively; P < 0.001), and leiomyoma (0.76 ± 0.14 and 0.77 ± 0.16, respectively; not significant, P > 0.1). CONCLUSIONS: Interobserver agreements in evaluating D, K, and ADC were moderate to excellent. D performed equally to conventional DWI in differentiating between benign and malignant uterine lesions. The mean K of malignant uterine lesions was significantly higher than that of non-tumorous myometrium or endometrium. |
format | Online Article Text |
id | pubmed-5703480 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-57034802017-12-08 Application of non-Gaussian water diffusional kurtosis imaging in the assessment of uterine tumors: A preliminary study Dia, Aliou Amadou Hori, Masatoshi Onishi, Hiromitsu Sakane, Makoto Ota, Takashi Tsuboyama, Takahiro Tatsumi, Mitsuaki Okuaki, Tomoyuki Tomiyama, Noriyuki PLoS One Research Article OBJECTIVES: To evaluate the interobserver reliability and value of diffusional kurtosis imaging (DKI) in the assessment of uterine tumors compared with those of conventional diffusion-weighted imaging (DWI). METHODS: This retrospective study was approved by our institutional review board, which waived the requirement for informed consent. Fifty-eight women (mean age: 55.0 ± 13.6 years; range: 30–89 years) with suspected malignant uterine tumors underwent 3-T magnetic resonance imaging using DKI and DWI. Twelve had coexisting leiomyoma. Two observers analyzed region-of-interest measurements of diffusivity (D), kurtosis (K), and the apparent diffusion coefficient (ADC) of uterine lesions and healthy adjacent tissues. Interobserver agreement was evaluated using the intra-class correlation coefficient (ICC). The mean values were compared using one-way analysis of variance with a post-hoc Tukey’s honestly significant difference test. The diagnostic accuracy of D and ADC in differentiating malignant tumors from benign leiomyomas was analyzed using receiver operating characteristic (ROC) analysis. RESULTS: The ICCs between the two observers in evaluating D, K, and the ADC of the malignant tumors were higher than 0.84, suggesting excellent interobserver agreements. The mean D (×10(−3) mm(2)/s) of uterine cancers (1.05 ± 0.41 and 1.09 ± 0.40 for observers 1 and 2, respectively) were significantly lower than those of leiomyoma (1.40 ± 0.37 and 1.56 ± 0.33, respectively; P < 0.05), healthy myometrium (1.72 ± 0.27 and 1.69 ± 0.30, respectively; P < 0.001), and healthy endometrium (1.53 ± 0.35 and 1.42 ± 0.37, respectively; P < 0.005). There was no significant difference in the area under the ROC curve between D and ADC. The mean K of uterine cancers (0.88 ± 0.28 and 0.90 ± 0.23, respectively) were higher than those of myometrium (0.72 ± 0.10 and 0.73 ± 0.10, respectively; P < 0.001), healthy endometrium (0.65 ± 0.13 and 0.60 ± 0.18, respectively; P < 0.001), and leiomyoma (0.76 ± 0.14 and 0.77 ± 0.16, respectively; not significant, P > 0.1). CONCLUSIONS: Interobserver agreements in evaluating D, K, and ADC were moderate to excellent. D performed equally to conventional DWI in differentiating between benign and malignant uterine lesions. The mean K of malignant uterine lesions was significantly higher than that of non-tumorous myometrium or endometrium. Public Library of Science 2017-11-27 /pmc/articles/PMC5703480/ /pubmed/29176867 http://dx.doi.org/10.1371/journal.pone.0188434 Text en © 2017 Dia et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Dia, Aliou Amadou Hori, Masatoshi Onishi, Hiromitsu Sakane, Makoto Ota, Takashi Tsuboyama, Takahiro Tatsumi, Mitsuaki Okuaki, Tomoyuki Tomiyama, Noriyuki Application of non-Gaussian water diffusional kurtosis imaging in the assessment of uterine tumors: A preliminary study |
title | Application of non-Gaussian water diffusional kurtosis imaging in the assessment of uterine tumors: A preliminary study |
title_full | Application of non-Gaussian water diffusional kurtosis imaging in the assessment of uterine tumors: A preliminary study |
title_fullStr | Application of non-Gaussian water diffusional kurtosis imaging in the assessment of uterine tumors: A preliminary study |
title_full_unstemmed | Application of non-Gaussian water diffusional kurtosis imaging in the assessment of uterine tumors: A preliminary study |
title_short | Application of non-Gaussian water diffusional kurtosis imaging in the assessment of uterine tumors: A preliminary study |
title_sort | application of non-gaussian water diffusional kurtosis imaging in the assessment of uterine tumors: a preliminary study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703480/ https://www.ncbi.nlm.nih.gov/pubmed/29176867 http://dx.doi.org/10.1371/journal.pone.0188434 |
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