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Promising new vaccine candidates against Campylobacter in broilers
Campylobacter is the leading cause of human bacterial gastroenteritis in the European Union. Birds represent the main reservoir of the bacteria, and human campylobacteriosis mainly occurs after consuming and/or handling poultry meat. Reducing avian intestinal Campylobacter loads should impact the in...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703506/ https://www.ncbi.nlm.nih.gov/pubmed/29176789 http://dx.doi.org/10.1371/journal.pone.0188472 |
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author | Meunier, Marine Guyard-Nicodème, Muriel Vigouroux, Estelle Poezevara, Typhaine Beven, Véronique Quesne, S. Bigault, Lionel Amelot, Michel Dory, Daniel Chemaly, Marianne |
author_facet | Meunier, Marine Guyard-Nicodème, Muriel Vigouroux, Estelle Poezevara, Typhaine Beven, Véronique Quesne, S. Bigault, Lionel Amelot, Michel Dory, Daniel Chemaly, Marianne |
author_sort | Meunier, Marine |
collection | PubMed |
description | Campylobacter is the leading cause of human bacterial gastroenteritis in the European Union. Birds represent the main reservoir of the bacteria, and human campylobacteriosis mainly occurs after consuming and/or handling poultry meat. Reducing avian intestinal Campylobacter loads should impact the incidence of human diseases. At the primary production level, several measures have been identified to reach this goal, including vaccination of poultry. Despite many studies, however, no efficient vaccine is currently available. We have recently identified new vaccine candidates using the reverse vaccinology strategy. This study assessed the in vivo immune and protective potential of six newly-identified vaccine antigens. Among the candidates tested on Ross broiler chickens, four (YP_001000437.1, YP_001000562.1, YP_999817.1, and YP_999838.1) significantly reduced cecal Campylobacter loads by between 2 and 4.2 log(10) CFU/g, with the concomitant development of a specific humoral immune response. In a second trial, cecal load reductions results were not statistically confirmed despite the induction of a strong immune response. These vaccine candidates need to be further investigated since they present promising features. |
format | Online Article Text |
id | pubmed-5703506 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-57035062017-12-08 Promising new vaccine candidates against Campylobacter in broilers Meunier, Marine Guyard-Nicodème, Muriel Vigouroux, Estelle Poezevara, Typhaine Beven, Véronique Quesne, S. Bigault, Lionel Amelot, Michel Dory, Daniel Chemaly, Marianne PLoS One Research Article Campylobacter is the leading cause of human bacterial gastroenteritis in the European Union. Birds represent the main reservoir of the bacteria, and human campylobacteriosis mainly occurs after consuming and/or handling poultry meat. Reducing avian intestinal Campylobacter loads should impact the incidence of human diseases. At the primary production level, several measures have been identified to reach this goal, including vaccination of poultry. Despite many studies, however, no efficient vaccine is currently available. We have recently identified new vaccine candidates using the reverse vaccinology strategy. This study assessed the in vivo immune and protective potential of six newly-identified vaccine antigens. Among the candidates tested on Ross broiler chickens, four (YP_001000437.1, YP_001000562.1, YP_999817.1, and YP_999838.1) significantly reduced cecal Campylobacter loads by between 2 and 4.2 log(10) CFU/g, with the concomitant development of a specific humoral immune response. In a second trial, cecal load reductions results were not statistically confirmed despite the induction of a strong immune response. These vaccine candidates need to be further investigated since they present promising features. Public Library of Science 2017-11-27 /pmc/articles/PMC5703506/ /pubmed/29176789 http://dx.doi.org/10.1371/journal.pone.0188472 Text en © 2017 Meunier et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Meunier, Marine Guyard-Nicodème, Muriel Vigouroux, Estelle Poezevara, Typhaine Beven, Véronique Quesne, S. Bigault, Lionel Amelot, Michel Dory, Daniel Chemaly, Marianne Promising new vaccine candidates against Campylobacter in broilers |
title | Promising new vaccine candidates against Campylobacter in broilers |
title_full | Promising new vaccine candidates against Campylobacter in broilers |
title_fullStr | Promising new vaccine candidates against Campylobacter in broilers |
title_full_unstemmed | Promising new vaccine candidates against Campylobacter in broilers |
title_short | Promising new vaccine candidates against Campylobacter in broilers |
title_sort | promising new vaccine candidates against campylobacter in broilers |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703506/ https://www.ncbi.nlm.nih.gov/pubmed/29176789 http://dx.doi.org/10.1371/journal.pone.0188472 |
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