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Blood serum metabolome of atopic dermatitis: Altered energy cycle and the markers of systemic inflammation
Atopic dermatitis is a chronic inflammatory disease which usually starts in the early childhood and ends before adulthood. However up to 3% of adults remain affected by the disease. The onset and course of the disease is influenced by various genetic and environmental factors. Although the immune sy...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703555/ https://www.ncbi.nlm.nih.gov/pubmed/29176763 http://dx.doi.org/10.1371/journal.pone.0188580 |
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author | Ottas, Aigar Fishman, Dmytro Okas, Tiia-Linda Püssa, Tõnu Toomik, Peeter Märtson, Aare Kingo, Külli Soomets, Ursel |
author_facet | Ottas, Aigar Fishman, Dmytro Okas, Tiia-Linda Püssa, Tõnu Toomik, Peeter Märtson, Aare Kingo, Külli Soomets, Ursel |
author_sort | Ottas, Aigar |
collection | PubMed |
description | Atopic dermatitis is a chronic inflammatory disease which usually starts in the early childhood and ends before adulthood. However up to 3% of adults remain affected by the disease. The onset and course of the disease is influenced by various genetic and environmental factors. Although the immune system has a great effect on the outcome of the disease, metabolic markers can also try to explain the background of atopic dermatitis. In this study we analyzed the serum of patients with atopic dermatitis using both targeted and untargeted metabolomics approaches. We found the most significant changes to be related to phosphatidylcholines, acylcarnitines and their ratios and a cleavage peptide of Fibrinogen A-α. These findings that have not been reported before will further help to understand this complex disease. |
format | Online Article Text |
id | pubmed-5703555 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-57035552017-12-08 Blood serum metabolome of atopic dermatitis: Altered energy cycle and the markers of systemic inflammation Ottas, Aigar Fishman, Dmytro Okas, Tiia-Linda Püssa, Tõnu Toomik, Peeter Märtson, Aare Kingo, Külli Soomets, Ursel PLoS One Research Article Atopic dermatitis is a chronic inflammatory disease which usually starts in the early childhood and ends before adulthood. However up to 3% of adults remain affected by the disease. The onset and course of the disease is influenced by various genetic and environmental factors. Although the immune system has a great effect on the outcome of the disease, metabolic markers can also try to explain the background of atopic dermatitis. In this study we analyzed the serum of patients with atopic dermatitis using both targeted and untargeted metabolomics approaches. We found the most significant changes to be related to phosphatidylcholines, acylcarnitines and their ratios and a cleavage peptide of Fibrinogen A-α. These findings that have not been reported before will further help to understand this complex disease. Public Library of Science 2017-11-27 /pmc/articles/PMC5703555/ /pubmed/29176763 http://dx.doi.org/10.1371/journal.pone.0188580 Text en © 2017 Ottas et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Ottas, Aigar Fishman, Dmytro Okas, Tiia-Linda Püssa, Tõnu Toomik, Peeter Märtson, Aare Kingo, Külli Soomets, Ursel Blood serum metabolome of atopic dermatitis: Altered energy cycle and the markers of systemic inflammation |
title | Blood serum metabolome of atopic dermatitis: Altered energy cycle and the markers of systemic inflammation |
title_full | Blood serum metabolome of atopic dermatitis: Altered energy cycle and the markers of systemic inflammation |
title_fullStr | Blood serum metabolome of atopic dermatitis: Altered energy cycle and the markers of systemic inflammation |
title_full_unstemmed | Blood serum metabolome of atopic dermatitis: Altered energy cycle and the markers of systemic inflammation |
title_short | Blood serum metabolome of atopic dermatitis: Altered energy cycle and the markers of systemic inflammation |
title_sort | blood serum metabolome of atopic dermatitis: altered energy cycle and the markers of systemic inflammation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703555/ https://www.ncbi.nlm.nih.gov/pubmed/29176763 http://dx.doi.org/10.1371/journal.pone.0188580 |
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