Cargando…

Prospects for Modeling Abnormal Neuronal Function in Schizophrenia Using Human Induced Pluripotent Stem Cells

Excitatory dopaminergic neurons, inhibitory GABAergic neurons, microglia, and oligodendrocytes have all been implicated in schizophrenia (SZ) network pathology. Still, SZ has been a difficult disorder to study, not only because of the limitations of animal models in capturing the complexity of the h...

Descripción completa

Detalles Bibliográficos
Autores principales: Prytkova, Iya, Brennand, Kristen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703699/
https://www.ncbi.nlm.nih.gov/pubmed/29217999
http://dx.doi.org/10.3389/fncel.2017.00360
_version_ 1783281730305654784
author Prytkova, Iya
Brennand, Kristen J.
author_facet Prytkova, Iya
Brennand, Kristen J.
author_sort Prytkova, Iya
collection PubMed
description Excitatory dopaminergic neurons, inhibitory GABAergic neurons, microglia, and oligodendrocytes have all been implicated in schizophrenia (SZ) network pathology. Still, SZ has been a difficult disorder to study, not only because of the limitations of animal models in capturing the complexity of the human mind, but also because it is greatly polygenic, with high rates of variability across the population. The advent of patient-derived pluripotent stem cells and induced neural and glial cultures has brought hope for modeling the molecular dysfunction underlying SZ pathology in a patient-specific manner. Here I review the successes of the patient-specific induced cultures in generating different cell types for the study of SZ, with special emphasis on the utility of co-culture techniques, both two- and three-dimensional, for modeling network dysfunction in disease.
format Online
Article
Text
id pubmed-5703699
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-57036992017-12-07 Prospects for Modeling Abnormal Neuronal Function in Schizophrenia Using Human Induced Pluripotent Stem Cells Prytkova, Iya Brennand, Kristen J. Front Cell Neurosci Neuroscience Excitatory dopaminergic neurons, inhibitory GABAergic neurons, microglia, and oligodendrocytes have all been implicated in schizophrenia (SZ) network pathology. Still, SZ has been a difficult disorder to study, not only because of the limitations of animal models in capturing the complexity of the human mind, but also because it is greatly polygenic, with high rates of variability across the population. The advent of patient-derived pluripotent stem cells and induced neural and glial cultures has brought hope for modeling the molecular dysfunction underlying SZ pathology in a patient-specific manner. Here I review the successes of the patient-specific induced cultures in generating different cell types for the study of SZ, with special emphasis on the utility of co-culture techniques, both two- and three-dimensional, for modeling network dysfunction in disease. Frontiers Media S.A. 2017-11-23 /pmc/articles/PMC5703699/ /pubmed/29217999 http://dx.doi.org/10.3389/fncel.2017.00360 Text en Copyright © 2017 Prytkova and Brennand. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Prytkova, Iya
Brennand, Kristen J.
Prospects for Modeling Abnormal Neuronal Function in Schizophrenia Using Human Induced Pluripotent Stem Cells
title Prospects for Modeling Abnormal Neuronal Function in Schizophrenia Using Human Induced Pluripotent Stem Cells
title_full Prospects for Modeling Abnormal Neuronal Function in Schizophrenia Using Human Induced Pluripotent Stem Cells
title_fullStr Prospects for Modeling Abnormal Neuronal Function in Schizophrenia Using Human Induced Pluripotent Stem Cells
title_full_unstemmed Prospects for Modeling Abnormal Neuronal Function in Schizophrenia Using Human Induced Pluripotent Stem Cells
title_short Prospects for Modeling Abnormal Neuronal Function in Schizophrenia Using Human Induced Pluripotent Stem Cells
title_sort prospects for modeling abnormal neuronal function in schizophrenia using human induced pluripotent stem cells
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703699/
https://www.ncbi.nlm.nih.gov/pubmed/29217999
http://dx.doi.org/10.3389/fncel.2017.00360
work_keys_str_mv AT prytkovaiya prospectsformodelingabnormalneuronalfunctioninschizophreniausinghumaninducedpluripotentstemcells
AT brennandkristenj prospectsformodelingabnormalneuronalfunctioninschizophreniausinghumaninducedpluripotentstemcells