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Factor H C-Terminal Domains Are Critical for Regulation of Platelet/Granulocyte Aggregate Formation

Platelet/granulocyte aggregates (PGAs) increase thromboinflammation in the vasculature, and PGA formation is tightly controlled by the complement alternative pathway (AP) negative regulator, Factor H (FH). Mutations in FH are associated with the prothrombotic disease atypical hemolytic uremic syndro...

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Detalles Bibliográficos
Autores principales:	Blatt, Adam Z., Saggu, Gurpanna, Cortes, Claudio, Herbert, Andrew P., Kavanagh, David, Ricklin, Daniel, Lambris, John D., Ferreira, Viviana P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703703/ https://www.ncbi.nlm.nih.gov/pubmed/29218045 http://dx.doi.org/10.3389/fimmu.2017.01586

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