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Peripheral Immune Alterations in Major Depression: The Role of Subtypes and Pathogenetic Characteristics
Depression has been associated with peripheral inflammatory processes and alterations in cellular immunity. Growing evidence suggests that immunological alterations may neither be necessary nor sufficient to induce depression in general, but seem to be associated with specific features. Using baseli...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703704/ https://www.ncbi.nlm.nih.gov/pubmed/29218020 http://dx.doi.org/10.3389/fpsyt.2017.00250 |
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author | Euteneuer, Frank Dannehl, Katharina del Rey, Adriana Engler, Harald Schedlowski, Manfred Rief, Winfried |
author_facet | Euteneuer, Frank Dannehl, Katharina del Rey, Adriana Engler, Harald Schedlowski, Manfred Rief, Winfried |
author_sort | Euteneuer, Frank |
collection | PubMed |
description | Depression has been associated with peripheral inflammatory processes and alterations in cellular immunity. Growing evidence suggests that immunological alterations may neither be necessary nor sufficient to induce depression in general, but seem to be associated with specific features. Using baseline data from the Outcome of Psychological Interventions in Depression trial, this exploratory study examines associations between depression subtypes and pathogenetic characteristics (i.e., melancholic vs non-melancholic depression, chronic vs non-chronic depression, age of onset, cognitive-affective and somatic symptom dimensions) with plasma levels of C-reactive protein (CRP), interleukin (IL)-6, IL-10, and numbers of leukocyte subpopulations in 98 patients with major depression (MD) and 30 age and sex-matched controls. Patients with MD exhibited higher CRP levels, higher neutrophil and monocyte counts, lower IL-10 levels, and an increased neutrophil to lymphocyte ratio (NLR) than controls. Patient with later age of onset had higher levels of two inflammatory markers (CRP, NLR) and lower cytotoxic T cell counts after adjusting for sociodemographics, lifestyle factors, and antidepressants. Furthermore, lower anti-inflammatory IL-10 levels were related to more severe somatic depressive symptoms. These results confirm and extend previous findings suggesting that increased levels of CRP are associated with a later onset of depression and demonstrate that also NLR as a subclinical inflammatory marker is related to a later onset of depression. |
format | Online Article Text |
id | pubmed-5703704 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-57037042017-12-07 Peripheral Immune Alterations in Major Depression: The Role of Subtypes and Pathogenetic Characteristics Euteneuer, Frank Dannehl, Katharina del Rey, Adriana Engler, Harald Schedlowski, Manfred Rief, Winfried Front Psychiatry Psychiatry Depression has been associated with peripheral inflammatory processes and alterations in cellular immunity. Growing evidence suggests that immunological alterations may neither be necessary nor sufficient to induce depression in general, but seem to be associated with specific features. Using baseline data from the Outcome of Psychological Interventions in Depression trial, this exploratory study examines associations between depression subtypes and pathogenetic characteristics (i.e., melancholic vs non-melancholic depression, chronic vs non-chronic depression, age of onset, cognitive-affective and somatic symptom dimensions) with plasma levels of C-reactive protein (CRP), interleukin (IL)-6, IL-10, and numbers of leukocyte subpopulations in 98 patients with major depression (MD) and 30 age and sex-matched controls. Patients with MD exhibited higher CRP levels, higher neutrophil and monocyte counts, lower IL-10 levels, and an increased neutrophil to lymphocyte ratio (NLR) than controls. Patient with later age of onset had higher levels of two inflammatory markers (CRP, NLR) and lower cytotoxic T cell counts after adjusting for sociodemographics, lifestyle factors, and antidepressants. Furthermore, lower anti-inflammatory IL-10 levels were related to more severe somatic depressive symptoms. These results confirm and extend previous findings suggesting that increased levels of CRP are associated with a later onset of depression and demonstrate that also NLR as a subclinical inflammatory marker is related to a later onset of depression. Frontiers Media S.A. 2017-11-23 /pmc/articles/PMC5703704/ /pubmed/29218020 http://dx.doi.org/10.3389/fpsyt.2017.00250 Text en Copyright © 2017 Euteneuer, Dannehl, del Rey, Engler, Schedlowski and Rief. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Euteneuer, Frank Dannehl, Katharina del Rey, Adriana Engler, Harald Schedlowski, Manfred Rief, Winfried Peripheral Immune Alterations in Major Depression: The Role of Subtypes and Pathogenetic Characteristics |
title | Peripheral Immune Alterations in Major Depression: The Role of Subtypes and Pathogenetic Characteristics |
title_full | Peripheral Immune Alterations in Major Depression: The Role of Subtypes and Pathogenetic Characteristics |
title_fullStr | Peripheral Immune Alterations in Major Depression: The Role of Subtypes and Pathogenetic Characteristics |
title_full_unstemmed | Peripheral Immune Alterations in Major Depression: The Role of Subtypes and Pathogenetic Characteristics |
title_short | Peripheral Immune Alterations in Major Depression: The Role of Subtypes and Pathogenetic Characteristics |
title_sort | peripheral immune alterations in major depression: the role of subtypes and pathogenetic characteristics |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703704/ https://www.ncbi.nlm.nih.gov/pubmed/29218020 http://dx.doi.org/10.3389/fpsyt.2017.00250 |
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