Cargando…

The inhibitory effect of minocycline on radiation-induced neuronal apoptosis via AMPKα1 signaling-mediated autophagy

Due to an increasing concern about radiation-induced cognitive deficits for brain tumor patients receiving radiation therapy, developing and evaluating countermeasures has become inevitable. Our previous study has found that minocycline, a clinical available antibiotics that can easily cross the blo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Liyuan, Huang, Ping, Chen, Hui, Tan, Wen, Lu, Jiawei, Liu, Wei, Wang, Jingdong, Zhang, Shuyu, Zhu, Wei, Cao, Jianping, Tian, Ye, Yang, Hongying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703722/ https://www.ncbi.nlm.nih.gov/pubmed/29180765 http://dx.doi.org/10.1038/s41598-017-16693-8

Ejemplares similares

miR-27a-containing Exosomes Secreted by Irradiated Skin Keratinocytes Delayed the Migration of Unirradiated Skin Fibroblasts
por: Tan, Wen, et al.
Publicado: (2019)

Radiation quality-dependence of bystander effect in unirradiated fibroblasts is associated with TGF-β1-Smad2 pathway and miR-21 in irradiated keratinocytes
por: Yin, Xiaoming, et al.
Publicado: (2015)

Microwave radiation induces neuronal autophagy through miR-30a-5p/AMPKα2 signal pathway
por: Hao, Yanhui, et al.
Publicado: (2022)

Minocycline ameliorates cognitive impairment induced by whole-brain irradiation: an animal study
por: Zhang, Liyuan, et al.
Publicado: (2014)

Calpain‐2 plays a pivotal role in the inhibitory effects of propofol against TNF‐α‐induced autophagy in mouse hippocampal neurons
por: Li, Ying, et al.
Publicado: (2020)

Periplocin Induces Apoptosis of Pancreatic Cancer Cells through Autophagy via the AMPK/mTOR Pathway
por: Zhang, Hewei, et al.
Publicado: (2022)

SQSTM1/p62 loss reverses the inhibitory effect of sunitinib on autophagy independent of AMPK signaling
por: Hou, Bolin, et al.
Publicado: (2019)

Inhibitory effects of minocycline on gliosis in the hydrocephalic H-Tx rat
por: Miller, Janet M, et al.
Publicado: (2006)

Aucubin prevents steroid‐induced osteoblast apoptosis by enhancing autophagy via AMPK activation
por: Yue, Chen, et al.
Publicado: (2021)

Effects of 3-Methyladenine on Microglia Autophagy and Neuronal Apoptosis After Radiation-Induced Brain Injury
por: Feng, Huichao, et al.
Publicado: (2022)

Kaempferol attenuated diabetic nephropathy by reducing apoptosis and promoting autophagy through AMPK/mTOR pathways
por: Sheng, Hongqin, et al.
Publicado: (2022)

Prevention of hypoglycemia-induced neuronal death by minocycline
por: Won, Seok Joon, et al.
Publicado: (2012)

Minocycline attenuates neuronal apoptosis and improves motor function after traumatic brain injury in rats
por: He, Jihong, et al.
Publicado: (2021)

Trifolirhizin induces autophagy-dependent apoptosis in colon cancer via AMPK/mTOR signaling
por: Sun, Dongdong, et al.
Publicado: (2020)

Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells
por: Chen, Long, et al.
Publicado: (2010)

Overexpression of miR-185 inhibits autophagy and apoptosis of dopaminergic neurons by regulating the AMPK/mTOR signaling pathway in Parkinson's disease
por: Wen, Zhi, et al.
Publicado: (2018)

AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumour cells
por: Harhaji-Trajkovic, L, et al.
Publicado: (2009)

Gastrin Enhances Autophagy and Promotes Gastric Carcinoma Proliferation via Inducing AMPKα
por: Kun, Zhuang, et al.
Publicado: (2017)

Diosmetin alleviates hypoxia-induced myocardial apoptosis by inducing autophagy through AMPK activation
por: Si, Qijun, et al.
Publicado: (2020)

Role of AMPK in autophagy
por: Wang, Shengyuan, et al.
Publicado: (2022)

Blocking AMPK/ULK1-dependent autophagy promoted apoptosis and suppressed colon cancer growth
por: Liu, Jing, et al.
Publicado: (2019)

Induction of Autophagy by Baicalin Through the AMPK-mTOR Pathway Protects Human Skin Fibroblasts from Ultraviolet B Radiation-Induced Apoptosis
por: Zhang, Jia-An, et al.
Publicado: (2020)

Minocycline attenuation of rat corpus callosum abnormality mediated by low-dose lipopolysaccharide-induced microglia activation
por: Zhang, Jingdong, et al.
Publicado: (2021)

Inhibitory mechanism of muscone in liver cancer involves the induction of apoptosis and autophagy
por: Qi, Wenchuan, et al.
Publicado: (2020)

Effects of minocycline on apoptosis and angiogenesis-related protein expression in a rat model of intracerebral hemorrhage☆
por: Wang, Ruizhi, et al.
Publicado: (2012)

Bisphenol a Induces Autophagy Defects and AIF-Dependent Apoptosis via HO-1 and AMPK to Degenerate N2a Neurons
por: Lee, Ching-Tien, et al.
Publicado: (2021)

Minocycline inhibits PARP-1 expression and decreases apoptosis in diabetic retinopathy
por: WU, YING, et al.
Publicado: (2015)

Irisin ameliorates neuroinflammation and neuronal apoptosis through integrin αVβ5/AMPK signaling pathway after intracerebral hemorrhage in mice
por: Wang, Yao, et al.
Publicado: (2022)

Metformin Protects Against Cisplatin-Induced Tubular Cell Apoptosis and Acute Kidney Injury via AMPKα-regulated Autophagy Induction
por: Li, Jianzhong, et al.
Publicado: (2016)

Melatonin and doxorubicin synergistically enhance apoptosis via autophagy-dependent reduction of AMPKα1 transcription in human breast cancer cells
por: Tran, Quynh Hoa, et al.
Publicado: (2021)

Autophagy in Rat Müller Glial Cells Is Modulated by the Sirtuin 4/AMPK/mTOR Pathway and Induces Apoptosis under Oxidative Stress
por: Qin, Mengqi, et al.
Publicado: (2022)

Magnoflorine Attenuates Cerebral Ischemia-Induced Neuronal Injury via Autophagy/Sirt1/AMPK Signaling Pathway
por: Liang, Hai, et al.
Publicado: (2022)

Direct protection of cultured neurons from ischemia-like injury by minocycline
por: Huang, Wendy C., et al.
Publicado: (2010)

Matrine attenuates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via maintaining AMPKα/UCP2 pathway
por: Hu, Can, et al.
Publicado: (2019)

Minocycline attenuates interferon-α-induced impairments in rat fear extinction
por: Bi, Qiang, et al.
Publicado: (2016)

Minocycline Induces Autophagy and Inhibits Cell Proliferation in LPS-Stimulated THP-1 Cells
por: Sun, Jian, et al.
Publicado: (2020)

Minocycline reduces neuroinflammation but does not ameliorate neuron loss in a mouse model of neurodegeneration
por: Cheng, Shanshan, et al.
Publicado: (2015)

VEGF Triggers Transient Induction of Autophagy in Endothelial Cells via AMPKα1
por: Spengler, Katrin, et al.
Publicado: (2020)

PARP-1 promotes autophagy via the AMPK/mTOR pathway in CNE-2 human nasopharyngeal carcinoma cells following ionizing radiation, while inhibition of autophagy contributes to the radiation sensitization of CNE-2 cells
por: CHEN, ZE-TAN, et al.
Publicado: (2015)

Minocycline reduces reactive gliosis in the rat model of hydrocephalus
por: Xu, Hao, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_nvj18h6rq3odtuio4l9hhlklof