Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

Vps34 PI3K is thought to be the main producer of phosphatidylinositol-3-monophosphate, a lipid that controls intracellular vesicular trafficking. The organismal impact of systemic inhibition of Vps34 kinase activity is not completely understood. Here we show that heterozygous Vps34 kinase-dead mice...

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Detalles Bibliográficos
Autores principales: Bilanges, Benoit, Alliouachene, Samira, Pearce, Wayne, Morelli, Daniele, Szabadkai, Gyorgy, Chung, Yuen-Li, Chicanne, Gaëtan, Valet, Colin, Hill, Julia M., Voshol, Peter J., Collinson, Lucy, Peddie, Christopher, Ali, Khaled, Ghazaly, Essam, Rajeeve, Vinothini, Trichas, Georgios, Srinivas, Shankar, Chaussade, Claire, Salamon, Rachel S., Backer, Jonathan M., Scudamore, Cheryl L., Whitehead, Maria A., Keaney, Erin P., Murphy, Leon O., Semple, Robert K., Payrastre, Bernard, Tooze, Sharon A., Vanhaesebroeck, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703854/
https://www.ncbi.nlm.nih.gov/pubmed/29180704
http://dx.doi.org/10.1038/s41467-017-01969-4

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