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OCT4 supports extended LIF-independent self-renewal and maintenance of transcriptional and epigenetic networks in embryonic stem cells

Embryonic stem (ES) cell pluripotency is governed by OCT4-centric transcriptional networks. Conventional ES cells can be derived and maintained in vitro with media containing the cytokine leukemia inhibitory factor (LIF), which propagates the pluripotent state by activating STAT3 signaling, and simu...

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Detalles Bibliográficos
Autores principales:	He, Runsheng, Xhabija, Besa, Al-Qanber, Batool, Kidder, Benjamin L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703885/ https://www.ncbi.nlm.nih.gov/pubmed/29180818 http://dx.doi.org/10.1038/s41598-017-16611-y

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