Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson’s disease models

While the pathogenesis of Parkinson’s disease (PD) is incompletely understood, mitochondrial dysfunction is thought to play a crucial role in disease pathogenesis. Here, we examined the relationship between mitochondrial function and dopamine neuron dysfunction and death using C. elegans mutants for...

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Detalles Bibliográficos
Autores principales: Cooper, Jason F., Machiela, Emily, Dues, Dylan J., Spielbauer, Katie K., Senchuk, Megan M., Van Raamsdonk, Jeremy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703891/
https://www.ncbi.nlm.nih.gov/pubmed/29180793
http://dx.doi.org/10.1038/s41598-017-16637-2

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