Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression

Mutations in E3 ubiquitin ligase Parkin have been linked to familial Parkinson’s disease. Accumulating evidence suggests that Parkin is a tumor suppressor, but the underlying mechanism is poorly understood. Here we show that Parkin is an E3 ubiquitin ligase for hypoxia-inducible factor 1α (HIF-1α)....

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Detalles Bibliográficos
Autores principales: Liu, Juan, Zhang, Cen, Zhao, Yuhan, Yue, Xuetian, Wu, Hao, Huang, Shan, Chen, James, Tomsky, Kyle, Xie, Haiyang, Khella, Christen A., Gatza, Michael L., Xia, Dajing, Gao, Jimin, White, Eileen, Haffty, Bruce G., Hu, Wenwei, Feng, Zhaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703960/
https://www.ncbi.nlm.nih.gov/pubmed/29180628
http://dx.doi.org/10.1038/s41467-017-01947-w

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