Autophagy protects pancreatic beta cell mass and function in the setting of a high-fat and high-glucose diet

Autophagy is a major regulator of pancreatic beta cell homeostasis. Altered autophagic activity has been implicated in the beta cells of patients with type 2 diabetes, and in the beta cells of obese diabetic rodents. Here, we show that autophagy was induced in beta cells by either a high-fat diet or...

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Detalles Bibliográficos
Autores principales: Sheng, Qingfeng, Xiao, Xiangwei, Prasadan, Krishna, Chen, Congde, Ming, Yungching, Fusco, Joseph, Gangopadhyay, Nupur N., Ricks, David, Gittes, George K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703965/
https://www.ncbi.nlm.nih.gov/pubmed/29180700
http://dx.doi.org/10.1038/s41598-017-16485-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703965/
https://www.ncbi.nlm.nih.gov/pubmed/29180700
http://dx.doi.org/10.1038/s41598-017-16485-0

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