Combined inhibition of MEK and nuclear ERK translocation has synergistic antitumor activity in melanoma cells

Genetic alterations in BRAF, NRAS and NF1 that activate the ERK cascade, account for over 80% of metastatic melanomas. However, ERK cascade inhibitors have been proven beneficial almost exclusively for BRAF mutant melanomas. One of the hallmarks of the ERK cascade is the nuclear translocation of ERK...

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Detalles Bibliográficos
Autores principales: Arafeh, Rand, Flores, Karen, Keren-Paz, Alona, Maik-Rachline, Galia, Gutkind, Naomi, Rosenberg, Steven, Seger, Rony, Samuels, Yardena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704016/
https://www.ncbi.nlm.nih.gov/pubmed/29180761
http://dx.doi.org/10.1038/s41598-017-16558-0

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