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A Route to Terahertz Metamaterial Biosensor Integrated with Microfluidics for Liver Cancer Biomarker Testing in Early Stage
Engineered Terahertz (THz) metamaterials presented an unique characteristics for biosensing application due to their accurately tunable resonance frequency, which is in accord with vibrational frequency of some important biomolecules such as cancer biomarker. However, water absorption in THz regime...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704020/ https://www.ncbi.nlm.nih.gov/pubmed/29180650 http://dx.doi.org/10.1038/s41598-017-16762-y |
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author | Geng, Zhaoxin Zhang, Xiong Fan, Zhiyuan Lv, Xiaoqing Chen, Hongda |
author_facet | Geng, Zhaoxin Zhang, Xiong Fan, Zhiyuan Lv, Xiaoqing Chen, Hongda |
author_sort | Geng, Zhaoxin |
collection | PubMed |
description | Engineered Terahertz (THz) metamaterials presented an unique characteristics for biosensing application due to their accurately tunable resonance frequency, which is in accord with vibrational frequency of some important biomolecules such as cancer biomarker. However, water absorption in THz regime is an obstacle to extend application in trace biomolecules of cancer antibody or antigen. Here, to overcome water absorption and enhance the THz biosensing sensitivity, two kinds of THz metamaterials biosensor integrated with microfluidics were fabricated and used to detect the Alpha fetoprotein (AFP) and Glutamine transferase isozymes II (GGT-II) of liver cancer biomarker in early stage. There were about 19 GHz resonance shift (5 mu/ml) and 14.2 GHz resonance shift (0.02524 μg/ml) for GGT-II and AFP with a two-gap-metamaterial, respectively, which agreed with simulation results. Those results demonstrated the power and usefulness of metamaterial-assisted THz spectroscopy in trace cancer biomarker molecular detection for biological and chemical sensing. Moreover, for a particular cancer biomarker, the sensitivity could be further improved by optimizing the metamaterial structure and decreasing the permittivity of the substrate. This method might be powerful and potential for special recognition of cancer molecules in the early stage. |
format | Online Article Text |
id | pubmed-5704020 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-57040202017-11-30 A Route to Terahertz Metamaterial Biosensor Integrated with Microfluidics for Liver Cancer Biomarker Testing in Early Stage Geng, Zhaoxin Zhang, Xiong Fan, Zhiyuan Lv, Xiaoqing Chen, Hongda Sci Rep Article Engineered Terahertz (THz) metamaterials presented an unique characteristics for biosensing application due to their accurately tunable resonance frequency, which is in accord with vibrational frequency of some important biomolecules such as cancer biomarker. However, water absorption in THz regime is an obstacle to extend application in trace biomolecules of cancer antibody or antigen. Here, to overcome water absorption and enhance the THz biosensing sensitivity, two kinds of THz metamaterials biosensor integrated with microfluidics were fabricated and used to detect the Alpha fetoprotein (AFP) and Glutamine transferase isozymes II (GGT-II) of liver cancer biomarker in early stage. There were about 19 GHz resonance shift (5 mu/ml) and 14.2 GHz resonance shift (0.02524 μg/ml) for GGT-II and AFP with a two-gap-metamaterial, respectively, which agreed with simulation results. Those results demonstrated the power and usefulness of metamaterial-assisted THz spectroscopy in trace cancer biomarker molecular detection for biological and chemical sensing. Moreover, for a particular cancer biomarker, the sensitivity could be further improved by optimizing the metamaterial structure and decreasing the permittivity of the substrate. This method might be powerful and potential for special recognition of cancer molecules in the early stage. Nature Publishing Group UK 2017-11-27 /pmc/articles/PMC5704020/ /pubmed/29180650 http://dx.doi.org/10.1038/s41598-017-16762-y Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Geng, Zhaoxin Zhang, Xiong Fan, Zhiyuan Lv, Xiaoqing Chen, Hongda A Route to Terahertz Metamaterial Biosensor Integrated with Microfluidics for Liver Cancer Biomarker Testing in Early Stage |
title | A Route to Terahertz Metamaterial Biosensor Integrated with Microfluidics for Liver Cancer Biomarker Testing in Early Stage |
title_full | A Route to Terahertz Metamaterial Biosensor Integrated with Microfluidics for Liver Cancer Biomarker Testing in Early Stage |
title_fullStr | A Route to Terahertz Metamaterial Biosensor Integrated with Microfluidics for Liver Cancer Biomarker Testing in Early Stage |
title_full_unstemmed | A Route to Terahertz Metamaterial Biosensor Integrated with Microfluidics for Liver Cancer Biomarker Testing in Early Stage |
title_short | A Route to Terahertz Metamaterial Biosensor Integrated with Microfluidics for Liver Cancer Biomarker Testing in Early Stage |
title_sort | route to terahertz metamaterial biosensor integrated with microfluidics for liver cancer biomarker testing in early stage |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704020/ https://www.ncbi.nlm.nih.gov/pubmed/29180650 http://dx.doi.org/10.1038/s41598-017-16762-y |
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