A Small Molecule Inhibitor of the β-Catenin-TCF4 Interaction Suppresses Colorectal Cancer Growth In Vitro and In Vivo

Colorectal cancer is associated with aberrant activation of the Wnt pathway. β-Catenin plays essential roles in the Wnt pathway by interacting with T-cell factor 4 (TCF4) to transcribe oncogenes. We synthesized a small molecule, referred to as HI-B1, and evaluated signaling changes and biological co...

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Detalles Bibliográficos
Autores principales: Shin, Seung Ho, Lim, Do Young, Reddy, Kanamata, Malakhova, Margarita, Liu, Fangfang, Wang, Ting, Song, Mengqiu, Chen, Hanyong, Bae, Ki Beom, Ryu, Joohyun, Liu, Kangdong, Lee, Mee-Hyun, Bode, Ann M., Dong, Zigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704052/
https://www.ncbi.nlm.nih.gov/pubmed/29033371
http://dx.doi.org/10.1016/j.ebiom.2017.09.029

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